Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, P.R. China.
Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, P.R. China.
Environ Toxicol Pharmacol. 2018 Mar;58:156-162. doi: 10.1016/j.etap.2018.01.002. Epub 2018 Jan 5.
To assess the adverse physiological changes induced by long-term exposure to PM2.5.
Totally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study.
A dose-response relationship between the FBG, HDL-c and CEA values and the PM2.5 exposure duration was observed. Multivariate analysis confirmed that one hour on duty outdoor per day for one year was associated with an increase in FBG of 0.005% (95% CI: 0.0004% to 0.009%), CEA of 0.012% (95% CI: 0.006% to 0.017%), and a decrease in HDL-C of 0.001% (95% CI: 0.00034% to 0.002%).
Long-term high air pollution exposure may lead to metabolism adaptation and it is likely involved in the development of cardiovascular disease and diabetes mellitus.
评估长期暴露于 PM2.5 引起的不良生理变化。
本研究共纳入 183 名交通警察和 88 名办公室警察作为对照组。分别获取交通警察和办公室警察工作场所的 PM2.5 浓度。对所有研究对象进行详细的个人问卷调查和常规实验室检查，包括血常规、空腹血糖、血脂、肝肾功能、免疫和肿瘤相关标志物。
观察到 FBG、HDL-c 和 CEA 值与 PM2.5 暴露时间之间存在剂量-反应关系。多变量分析证实，每天户外工作 1 小时，每年可使 FBG 增加 0.005%（95%CI：0.0004%至 0.009%）、CEA 增加 0.012%（95%CI：0.006%至 0.017%）和 HDL-C 减少 0.001%（95%CI：0.00034%至 0.002%）。
长期暴露于高空气污染可能导致代谢适应，这可能与心血管疾病和糖尿病的发生有关。
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