Yin Tingting, Zhang Tingting, Ma Lei
College of Life Science, Shihezi University, Shihezi, Xinjiang, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jan 25;18:267-286. doi: 10.2147/CCID.S499202. eCollection 2025.
There are significant inflammatory correlations and common immune dysregulation features between psoriasis and chronic kidney disease, however, the inflammatory mechanisms of these two diseases have not been clarified. The aim of this study was to screen immunologically related biomarkers for psoriasis and chronic kidney disease with the objective of identifying specific molecular markers to improve the accuracy and sensitivity of disease diagnosis.
To achieve this objective, common differentially expressed genes between psoriasis and chronic kidney disease were first identified. Through further functional analysis, these genes were found to be primarily involved in the activation of inflammation and innate immune responses. Subsequently, six hub genes were determined using five topological algorithms. The responses of these two diseases exhibited similar changes in immune reactions. By cross-analyzing these key genes with known immune genes, three Immunity-Related Hub Genes (IRHGs) were identified, including , and .
ROC curve analysis validated the excellent discriminative ability of and in both diseases. Furthermore, immune infiltration analysis revealed a higher abundance of T cells in samples from both psoriasis and chronic kidney disease, suggesting that T cell-driven immune responses may play a crucial role in the association of these two diseases. Lastly, single-cell analysis observed a significant increase in the cell abundance of T cells and endothelial cells in psoriasis and chronic kidney disease, respectively. The differential expression of , and in these cells suggests that they may be involved to varying degrees in the pathogenic mechanisms of the two diseases.
This study provides a theoretical foundation for prognosis assessment and treatment of psoriasis and chronic kidney disease, contributing to a deeper understanding of the immune mechanisms underlying these conditions.
银屑病与慢性肾脏病之间存在显著的炎症相关性及共同的免疫失调特征，但这两种疾病的炎症机制尚未阐明。本研究旨在筛选银屑病和慢性肾脏病的免疫相关生物标志物，以确定特异性分子标志物，提高疾病诊断的准确性和敏感性。
为实现这一目标，首先确定了银屑病和慢性肾脏病之间共同的差异表达基因。通过进一步的功能分析，发现这些基因主要参与炎症激活和固有免疫反应。随后，使用五种拓扑算法确定了六个核心基因。这两种疾病的反应在免疫反应中表现出相似的变化。通过将这些关键基因与已知免疫基因进行交叉分析，确定了三个免疫相关核心基因（IRHG），包括 、 和 。
ROC曲线分析验证了 和 在两种疾病中均具有出色的鉴别能力。此外，免疫浸润分析显示，银屑病和慢性肾脏病样本中T细胞丰度更高，表明T细胞驱动的免疫反应可能在这两种疾病的关联中起关键作用。最后，单细胞分析观察到银屑病和慢性肾脏病中T细胞和内皮细胞的细胞丰度分别显著增加。 、 和 在这些细胞中的差异表达表明它们可能在不同程度上参与了这两种疾病的致病机制。
本研究为银屑病和慢性肾脏病的预后评估及治疗提供了理论基础，有助于更深入地了解这些疾病潜在的免疫机制。
