Menck C F, Cabral-Neto J B, Faljoni-Alário A, Alcantara-Gomes R
Mutat Res. 1986 Jan;165(1):9-14. doi: 10.1016/0167-8817(86)90003-9.
Exposure of lambda phage to triplet acetone, generated via the oxidation of isobutanal by peroxidase, leads to genome lesions. The majority of these lesions are detected as DNA single-strand breaks only under alkaline conditions, and so true breaks do not occur. Also, no sites sensitive to UV-endonuclease from Micrococcus luteus were found in DNA from treated phage. The participation of triplet acetone in the generation of such DNA damage is discussed.
