桑叶及其对抗心血管代谢风险的潜在作用：化学成分、生物学特性和临床疗效综述。
Mulberry leaves and their potential effects against cardiometabolic risks: a review of chemical compositions, biological properties and clinical efficacy.
机构信息
a Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences , Chulalongkorn University , Bangkok , Thailand.
b Department of Surgery, Faculty of Medicine, Plastic and Maxillofacial Surgery , Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
出版信息
Pharm Biol. 2018 Dec;56(1):109-118. doi: 10.1080/13880209.2018.1424210.
CONTEXT
Cardiometabolic risks are regarded as the crucial factors associated with type 2 diabetes (T2DM) and cardiovascular diseases (CVD). Regarding an increased attention to medicinal plants in the current healthcare system, the effects of mulberry (Morus spp., Moraceae) leaves on cardiometabolic risks have been consecutively considered in scientific research.
OBJECTIVE
The present review compiles and summarizes the chemical compositions, biological properties and clinical efficacy of mulberry leaves that are related to the amelioration of cardiometabolic risks.
METHODS
Published English literature from the PubMed, Science Direct and Google Scholar databases was searched by using 'mulberry leaves' 'Morus spp.', 'hyperglycemia', 'hyperlipidemia', 'obesity', 'hypertension', 'oxidative stress', 'atherosclerosis' and 'cardiovascular diseases' as the keywords. The relevant articles published over the past two decades were identified and reviewed.
RESULTS
Mulberry leaves contain numerous chemical constituents. 1-Deoxynojirimycin (DNJ), phenolics and flavonoids are the prominent functional compounds. Preclinical and clinical studies showed that mulberry leaves possessed various beneficial effects against cardiometabolic risks, including antihyperglycaemic, antihyperlipidaemic, antiobesity, antihypertensive, antioxidative, anti-inflammatory, anti-atherosclerotic and cardioprotective effects.
CONCLUSIONS
Mulberry leaves could be a promising therapeutic option for modulating cardiometabolic risks. However, further investigations should be performed to substantiate the potential of mulberry leaves in practical uses.
背景
心血管代谢风险被认为是与 2 型糖尿病（T2DM）和心血管疾病（CVD）相关的关键因素。鉴于当前医疗保健系统中对药用植物的关注度不断提高，桑叶对心血管代谢风险的影响在科学研究中相继得到了关注。
目的
本综述综合总结了桑叶改善心血管代谢风险的相关化学组成、生物学特性和临床疗效。
方法
使用“桑叶”“桑属”“高血糖”“高血脂”“肥胖”“高血压”“氧化应激”“动脉粥样硬化”和“心血管疾病”等关键词，在 PubMed、Science Direct 和 Google Scholar 数据库中检索发表的英文文献。确定并回顾了过去 20 年发表的相关文章。
结果
桑叶含有多种化学成分，其中 1-脱氧野尻霉素（DNJ）、酚类和类黄酮是主要的功能性化合物。临床前和临床研究表明，桑叶对心血管代谢风险具有多种有益作用，包括降血糖、降血脂、减肥、降压、抗氧化、抗炎、抗动脉粥样硬化和心脏保护作用。
结论
桑叶可能是调节心血管代谢风险的一种有前途的治疗选择。然而，需要进一步的研究来证实桑叶在实际应用中的潜力。
Zotero 插件