Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79079-900, Brazil.
Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79079-900, Brazil.
Int J Mol Sci. 2019 Jan 14;20(2):301. doi: 10.3390/ijms20020301.
Many populations use medicinal plants as a therapeutic treatment, due to their lower cost and greater access. Among the plant species used for medicinal purposes are those of the genus . The most known species are , , and This review aims to collect data from the literature, predominantly from cell and animal studies, which presents a possible nutraceutical and medicinal potential of the species for use in metabolic dysfunctions. The fruits and leaves of mulberry are used for therapeutic purposes. For scientific confirmation of these effects, they were studied for laxative properties, antibacterial activity, anti-atherogenic activity, and hepatoprotective function. Furthermore, the genus is recognized for the treatment and prevention of diabetes mellitus, through its hypoglycemic action. It may also provide health benefits through immunomodulatory, anti-inflammatory, and anti-nociceptive effects. It has been found that the species have phenolic compounds, flavonoids, and anthocyanins that act as important antioxidants and promote beneficial effects on human health. These phytochemical compounds differ among species. Blackberry () are rich in flavonoids, while the white mulberry () has low concentrations of flavonoids and anthocyanins. In addition, another important factor is to ensure a complete exemption of toxic risks in the use of medicinal plants for the treatment of diseases. Studies have shown no toxic effects by the administration of extracts of species. Thus, the mulberry tree presents nutraceutical potential. It is therefore a promising alternative for medicinal products based on medicinal plants.
许多人群将药用植物作为治疗方法，因为它们成本更低且更容易获得。用于药用目的的植物物种包括 属的物种。最知名的物种是 、 和 。本综述旨在收集文献中的数据，主要来自细胞和动物研究，这些研究展示了 属的物种在代谢功能障碍方面具有潜在的营养和药用价值。桑树的果实和叶子可用于治疗用途。为了科学证实这些效果，对它们的通便特性、抗菌活性、抗动脉粥样硬化活性和保肝功能进行了研究。此外， 属还因其降血糖作用而被用于治疗和预防糖尿病。它还可能通过免疫调节、抗炎和镇痛作用提供健康益处。研究发现， 属的物种具有酚类化合物、类黄酮和花青素，它们作为重要的抗氧化剂，对人类健康有有益的影响。这些植物化学化合物在不同物种之间存在差异。黑莓（ ）富含类黄酮，而白桑（ ）的类黄酮和花青素含量较低。此外，另一个重要因素是确保在使用药用植物治疗疾病时完全避免毒性风险。研究表明， 属物种的提取物没有毒性作用。因此，桑树具有营养潜力。它因此是基于药用植物的药用产品的有前途的替代物。
