Khan Mehak Nawaz, Khan Abdul Majeed, Ullah Hamid, Hussain Sajjad, Khattak Azim Khan
Institute of Chemical Sciences, Gomal University, D I Khan, KPK, Pakistan.
General Studies Department JIC, Jubail Industrial City, Kingdom of Saudi Arabia.
Pak J Pharm Sci. 2018 Jan;31(1):103-111.
A Schiff base 3 has been synthesized by equimolar reaction (condensation) of sulfonamide i.e. sulfamethoxypyridazine 1 and substituted aromatic aldehyde i.e. 2-Hydroxy-1-Napthalene aldehyde 2. The synthesized Schiff base 3 and its Metal (II) complexes were characterized by its physical, analytical (CHN analysis) and spectral (UV & IR) analysis. The Staphylococcus aureus and Escherichia coli bacterial strains were used for antibacterial activity of Sulfamethoxypyridazine 1, its Schiff base 3 and its transition metal (II) complexes 4-8. All of them showed varied levels of activity.
通过磺胺类药物即磺胺甲氧嗪1与取代芳香醛即2-羟基-1-萘醛2的等摩尔反应（缩合）合成了席夫碱3。通过物理、分析（CHN分析）和光谱（紫外和红外）分析对合成的席夫碱3及其金属（II）配合物进行了表征。使用金黄色葡萄球菌和大肠杆菌菌株对磺胺甲氧嗪1、其席夫碱3及其过渡金属（II）配合物4-8进行抗菌活性测试。它们均表现出不同程度的活性。
