Mulyana Roza, Setiati Siti, Martini Rose D, Harimurti Kuntjoro, Dwimartutie Noto
Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Sumatera Barat, Indonesia.
Acta Med Indones. 2017 Oct;49(4):324-329.
a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia.
the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23.5 and albumin level <3.5 g/dL. A total of 109 subjects were randomly divided into two groups: one group received 10 g Ophiocephalus striatus extract per day for 14 days and another group received placebo. Albumin and IGF-1 levels were obtained before and after intervention.
ninety subjects completed the study (extract group=45 subjects; placebo group =45 subjects) for 14 days. The median of age were 69 (64;75) years and the male to female ratio were 2 : 3. The changes of IGF-1 and albumin levels from before to after intervention between extract group compared to placebo group were 14.7 (0.30;31.5) ng/mL vs 1.0 (-6;13.15) ng/mL (p=0.002) and 0.5 (0.15;0.70) g/dL vs 0.10 (0.0;0.50) g/dL (p=0.003), respectively. There were significant differences in the improvement of IGF-1 and albumin levels between extract and placebo group.
supplementation of Ophiocephalus striatus extract was associated with a significant increase in IGF-1 and albumin levels in elderly patients with hypoalbuminemia.
淡水鱼条纹蛇鲻，在印度尼西亚当地称为哈鲁安，因其所含的氨基酸、脂肪酸、维生素和矿物质，可能会提高低蛋白血症老年患者的胰岛素样生长因子-1（IGF-1）和白蛋白水平。本研究旨在调查条纹蛇鲻提取物对低蛋白血症老年患者IGF-1和白蛋白水平的影响。
本研究为双盲随机对照试验，纳入了营养不良的老年住院患者（≥60岁），这些患者在出院前正从急性疾病中康复，其微型营养评定量表评分≤23.5且白蛋白水平<3.5g/dL。总共109名受试者被随机分为两组：一组每天服用10g条纹蛇鲻提取物，共14天，另一组服用安慰剂。在干预前后测定白蛋白和IGF-1水平。
90名受试者完成了为期14天的研究（提取物组=45名受试者；安慰剂组=45名受试者）。年龄中位数为69（64；75）岁，男女比例为2:3。提取物组与安慰剂组干预前后IGF-1水平的变化分别为14.7（0.30；31.5）ng/mL和1.0（-6；13.15）ng/mL（p=0.002），白蛋白水平的变化分别为0.5（0.15；0.70）g/dL和0.10（0.0；0.50）g/dL（p=0.003）。提取物组和安慰剂组在IGF-1和白蛋白水平改善方面存在显著差异。
补充条纹蛇鲻提取物与低蛋白血症老年患者IGF-1和白蛋白水平的显著升高有关。
