Riviati Nur, Legiran Legiran, Saleh Irsan, Indrajaya Taufik, Ali Zulkhair
Internal Medicine Department, Medical Faculty, Sriwijaya University, Palembang 30126, Indonesia.
Biomedicine Department, Dr. Mohammad Hoesin Hospital, Faculty of Medicine, Sriwijaya University, Palembang 30139, Indonesia.
Geriatrics (Basel). 2024 Mar 7;9(2):35. doi: 10.3390/geriatrics9020035.
Sarcopenia, a condition characterized by muscle loss and decreased function in older adults, is a growing public health concern. This study aimed to investigate the effects of extract on insulin-like growth factor-1 serum, interleukin-6 serum levels, and sarcopenia-related parameters in older adults with sarcopenia. This double-blind randomized controlled trial included 80 older adults with sarcopenia. Participants were randomly assigned to receive extract or a placebo for two weeks. The IGF-1 serum and IL-6 serum levels were assessed as primary outcomes. The extract intervention resulted in a significant reduction in serum IL-6 levels. Although the IGF-1 levels did not show significant changes, there was an increase for the intervention group. This study demonstrated that a 2-week intervention with Ophiocephalus striatus extract positively impacted the serum IL-6 levels in older adults with sarcopenia. While the IGF-1 levels did not change significantly in this short intervention period, the observed improvements in IGF-1, calf circumference, muscle mass, and muscle strength are promising. The findings suggest that Ophiocephalus striatus extract may offer a valuable intervention for managing sarcopenia, particularly in regions with abundant Ophiocephalus striatus production, such as South Sumatera. This study was registered with trial number NCT05869383.
肌肉减少症是一种以老年人肌肉流失和功能下降为特征的疾病，日益引起公众对健康的关注。本研究旨在调查[提取物名称]提取物对患有肌肉减少症的老年人血清胰岛素样生长因子-1、血清白细胞介素-6水平以及与肌肉减少症相关参数的影响。这项双盲随机对照试验纳入了80名患有肌肉减少症的老年人。参与者被随机分配接受[提取物名称]提取物或安慰剂，为期两周。评估血清IGF-1和血清IL-6水平作为主要结局。[提取物名称]提取物干预导致血清IL-6水平显著降低。虽然IGF-1水平没有显示出显著变化，但干预组有所升高。本研究表明，用线纹尖塘鳢提取物进行为期2周的干预对患有肌肉减少症的老年人血清IL-6水平有积极影响。虽然在这个短期干预期间IGF-1水平没有显著变化，但观察到的IGF-1、小腿围度、肌肉质量和肌肉力量的改善是有前景的。研究结果表明，线纹尖塘鳢提取物可能为管理肌肉减少症提供有价值的干预措施，特别是在像南苏门答腊这样线纹尖塘鳢产量丰富的地区。本研究已在试验编号NCT05869383下注册。
