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在肝移植中使用主动脉-肝动脉导管替代标准动脉吻合术

Placement of an Aortohepatic Conduit as an Alternative to Standard Arterial Anastomosis in Liver Transplantation.

作者信息

Jung Dong-Hwan, Park Cheon-Soo, Ha Tae-Yong, Song Gi-Won, Park Gil-Chun, Cho Yong-Pil, Lee Sung-Gyu

机构信息

Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea.

Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea.

出版信息

Ann Transplant. 2018 Jan 19;23:61-65. doi: 10.12659/aot.906307.

Abstract

BACKGROUND The aim of this study was to assess the impact of placement of an aortohepatic conduit on graft and patient survival after liver transplantation (LT) in selected patients with an inadequate recipient hepatic artery (HA) for a standard arterial anastomosis. MATERIAL AND METHODS Of 331 patients who underwent deceased donor LT, 25 (7.6%) who received placement of an aortohepatic conduit at the time of transplantation were included. Clinical characteristics and outcomes, including postoperative complications, conduit patency, and graft and patient survival rates, were analyzed. RESULTS All 25 patients included in this study presented a high preoperative Model for End-stage Liver Disease score (25.4±8.6; range, 6-42) and high rates of retransplantation (n=11, 44%) or previous abdominal - pelvic surgery (n=5, 20%). The observed postoperative vascular complications were portal vein thrombosis in 3 cases (12%) and anastomosis-site bleeding of the aortohepatic conduit in 1 case (4%); there was no HA thrombosis or stenosis in our analysis. With a median follow-up of 37 months (range, 0-69 months), all aortohepatic conduits were patent, and the graft and patient survival rates were 84% and 68%, respectively. The causes of death were graft failure (n=4), pneumonia (n=3), and cerebrovascular accidents (n=1). CONCLUSIONS Our results indicate that placement of an aortohepatic conduit is a feasible alternative to a standard arterial anastomosis in selected patients whose HA and surrounding potential inflow arteries are not suitable for standard arterial anastomosis.

摘要

背景 本研究的目的是评估在选定的肝动脉(HA)不足以进行标准动脉吻合的患者中,植入主动脉-肝动脉导管对肝移植(LT)后移植物和患者生存的影响。材料与方法 在331例行尸体供肝LT的患者中,纳入25例(7.6%)在移植时接受主动脉-肝动脉导管植入的患者。分析临床特征和结局,包括术后并发症、导管通畅情况、移植物和患者生存率。结果 本研究纳入的所有25例患者术前终末期肝病模型评分均较高(25.4±8.6;范围6 - 42),再次移植率(n = 11,44%)或既往腹部-盆腔手术率(n = 5,20%)也较高。观察到的术后血管并发症为3例(12%)门静脉血栓形成和1例(4%)主动脉-肝动脉导管吻合口出血;在我们的分析中未发现HA血栓形成或狭窄。中位随访37个月(范围0 - 69个月),所有主动脉-肝动脉导管均通畅,移植物和患者生存率分别为84%和68%。死亡原因是移植物功能衰竭(n = 4)、肺炎(n = 3)和脑血管意外(n = 1)。结论 我们的结果表明,在HA和周围潜在流入动脉不适合进行标准动脉吻合的选定患者中,植入主动脉-肝动脉导管是标准动脉吻合的一种可行替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35a9/6248308/392a1a35936a/anntransplant-23-61-g001.jpg

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