Department of Gastroenterology and Hepatology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, 100071, China.
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94143-0912, USA.
Sci Rep. 2018 Jan 18;8(1):1066. doi: 10.1038/s41598-018-19203-6.
The aim of this study was to evaluate the feasibility of a novel bracing basket for Endoscopic submucosal tunnel dissection (ESTD), which was developed for improved effectiveness and ease of use. This was a prospective randomized, comparative, experimental animal study carried out at a single center. The primary aim was to evaluate the efficacy of ESTD with a novel bracing basket, compared with conventional ESTD. The secondary aims were to assess the quality control of the procedures and adverse events. Twenty procedures (6 esophageal and 14 gastric) were performed in four pigs. All resections were completed as en bloc resections. The technical success rate was 100% for both techniques (bracing basket-assisted ESTD vs. conventional ESTD). The procedure times were similar, but the cutting speed was quicker with bracing basket-assisted ESTD in gastric (antrum:23.3 ± 2.2 mm/min vs. 15.2 ± 3.2 mm/min, body: 26.1 ± 1.3 mm/min vs. 18.4 ± 2.0 mm/min, p < 0.05). There was one bleeding in the bracing basket-assisted ESTD group and one perforation in the conventional ESTD group. Compared with conventional ESTD, the use of this basket has potential advantages. Comparison studies with larger gastric or colorectal lesions treated with conventional ESTD are needed.
本研究旨在评估一种新型支撑篮在经内镜黏膜下隧道剥离术（ESTD）中的应用的可行性，该支撑篮旨在提高有效性和易用性。这是一项在单中心进行的前瞻性随机、对照、实验动物研究。主要目的是评估新型支撑篮辅助 ESTD 的疗效与传统 ESTD 的比较。次要目的是评估手术的质量控制和不良事件。在四只猪中进行了 20 例手术（6 例食管和 14 例胃）。所有切除均为整块切除。两种技术的技术成功率均为 100%（支撑篮辅助 ESTD 与传统 ESTD）。两种技术的手术时间相似，但支撑篮辅助 ESTD 胃（胃窦：23.3±2.2mm/min 与 15.2±3.2mm/min，胃体：26.1±1.3mm/min 与 18.4±2.0mm/min，p<0.05）的切割速度更快。支撑篮辅助 ESTD 组有 1 例出血，传统 ESTD 组有 1 例穿孔。与传统 ESTD 相比，这种篮的使用具有潜在的优势。需要与使用传统 ESTD 治疗更大的胃或结直肠病变的对照研究进行比较。
