Liu Yulong, Ge Rongjing, Zhao Xin, Guo Rui, Huang Li, Zhao Shidi, Guan Sudong, Lu Wei, Cui Shan, Wang Shirlene, Wang Jin-Hui
Department of Pathophysiology, Bengbu Medical College, Anhui 233000, China.
Qingdao University, School of Pharmacy, Shandong 266021, China.
Oncotarget. 2017 Aug 4;8(68):112401-112416. doi: 10.18632/oncotarget.19918. eCollection 2017 Dec 22.
The capabilities of learning and memory in parents are presumably transmitted to their offsprings, in which genetic codes and epigenetic regulations are thought as molecular bases. As neural plasticity occurs during memory formation as cellular mechanism, we aim to examine the correlation of activity strengths at cortical glutamatergic and GABAergic neurons to the transgenerational inheritance of learning ability. In a mouse model of associative learning, paired whisker and odor stimulations led to odorant-induced whisker motion, whose onset appeared fast (high learning efficiency, HLE) or slow (low learning efficiency, LLE). HLE male and female mice, HLE female and LLE male mice as well as HLE male and LLE female mice were cross-mated to have their first generation of offsprings, filials (F1). The onset of odorant-induced whisker motion appeared a sequence of high-to-low efficiency in three groups of F1 mice that were from HLE male and female mice, HLE female and LLE male mice as well as HLE male and LLE female mice. Activities related to glutamatergic neurons in barrel cortices appeared a sequence of high-to-low strength in these F1 mice from HLE male and female mice, HLE female and LLE male mice as well as HLE male and LLE female mice. Activities related to GABAergic neurons in barrel cortices appeared a sequence of low-to-high strength in these F1 mice from HLE male and female mice, HLE female and LLE male mice as well as HLE male and LLE female mice. Neuronal activity strength was linearly correlated to learning efficiency among three groups. Thus, the coordinated activities at glutamatergic and GABAergic neurons may constitute the cellular basis for the transgenerational inheritance of learning ability.
亲本的学习和记忆能力大概会传递给它们的后代,其中遗传密码和表观遗传调控被认为是分子基础。由于神经可塑性作为细胞机制在记忆形成过程中发生,我们旨在研究皮质谷氨酸能神经元和γ-氨基丁酸能神经元的活动强度与学习能力的跨代遗传之间的相关性。在一个联想学习的小鼠模型中,配对的触须和气味刺激导致气味诱导的触须运动,其开始速度有快(高学习效率,HLE)或慢(低学习效率,LLE)之分。将HLE雄性和雌性小鼠、HLE雌性和LLE雄性小鼠以及HLE雄性和LLE雌性小鼠进行杂交,产生它们的第一代后代,即子代(F1)。在来自HLE雄性和雌性小鼠、HLE雌性和LLE雄性小鼠以及HLE雄性和LLE雌性小鼠的三组F1小鼠中,气味诱导的触须运动的开始呈现出从高到低的效率顺序。在这些来自HLE雄性和雌性小鼠、HLE雌性和LLE雄性小鼠以及HLE雄性和LLE雌性小鼠的F1小鼠中,桶状皮质中与谷氨酸能神经元相关的活动呈现出从高到低的强度顺序。在这些来自HLE雄性和雌性小鼠、HLE雌性和LLE雄性小鼠以及HLE雄性和LLE雌性小鼠的F1小鼠中,桶状皮质中与γ-氨基丁酸能神经元相关的活动呈现出从低到高的强度顺序。三组之间神经元活动强度与学习效率呈线性相关。因此,谷氨酸能神经元和γ-氨基丁酸能神经元的协同活动可能构成学习能力跨代遗传的细胞基础。