Department of Hand Surgery, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China.
Department of Central Laboratory, Jing'an District Centre Hospital, Shanghai, China.
Neural Plast. 2017;2017:5101925. doi: 10.1155/2017/5101925. Epub 2017 Nov 16.
Peripheral nerve compression is reported to induce cortical plasticity, which was well pictured by former researches. However, the longitudinal changes brought by surgical treatment are not clear. In this research, 18 subjects who suffered from bilateral carpal tunnel syndrome were evaluated using task-dependent fMRI and electromyography assessment before and after surgery. The third digit was tactually simulated by von Frey filaments. The results demonstrated that the pattern of activation was similar but a decreased extent of activation in the postcentral gyrus, inferior frontal lobe, superior frontal lobe, and parahippocampal gyrus after surgery was found. The correlation analysis showed a significant correlation between the decreased number of activated voxels and the improvement of EMG performance. This result implied a potential connection between fMRI measurement and clinical improvement.
周围神经压迫据报道可诱导皮质可塑性，这在前人的研究中已有很好的描述。然而，手术治疗带来的纵向变化尚不清楚。在这项研究中，18 名双侧腕管综合征患者在手术前后分别接受了任务相关 fMRI 和肌电图评估。使用 von Frey 纤维模拟第三指触觉。结果表明，激活模式相似，但术后中央后回、下额叶、上额叶和海马旁回的激活程度降低。相关性分析表明，激活体素数量的减少与肌电图表现的改善呈显著相关。这一结果暗示了 fMRI 测量与临床改善之间的潜在联系。
