Barthas Florent, Kwan Alex C
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06511, USA.
Trends Neurosci. 2017 Mar;40(3):181-193. doi: 10.1016/j.tins.2016.11.006. Epub 2016 Dec 22.
In rodents, the medial aspect of the secondary motor cortex (M2) is known by other names, including medial agranular cortex (AGm), medial precentral cortex (PrCm), and frontal orienting field (FOF). As a subdivision of the medial prefrontal cortex (mPFC), M2 can be defined by a distinct set of afferent and efferent connections, microstimulation responses, and lesion outcomes. However, the behavioral role of M2 remains mysterious. Here, we focus on evidence from rodent studies, highlighting recent findings of early and context-dependent choice-related activity in M2 during voluntary behavior. Based on the current understanding, we suggest that a major function for M2 is to flexibly map antecedent signals such as sensory cues to motor actions, thereby enabling adaptive choice behavior.
在啮齿动物中，次级运动皮层（M2）的内侧部分还有其他名称，包括内侧无颗粒皮层（AGm）、内侧中央前皮层（PrCm）和额叶定向场（FOF）。作为内侧前额叶皮层（mPFC）的一个细分区域，M2可以通过一组独特的传入和传出连接、微刺激反应以及损伤结果来定义。然而，M2的行为作用仍然是个谜。在这里，我们重点关注来自啮齿动物研究的证据，突出了近期关于M2在自愿行为期间与早期和情境相关的选择相关活动的发现。基于目前的理解，我们认为M2的一个主要功能是灵活地将诸如感觉线索等先前信号映射到运动动作，从而实现适应性选择行为。
