Division of Cardiothoracic Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Division of Gastroenterology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Surg Endosc. 2018 Jul;32(7):3357-3363. doi: 10.1007/s00464-018-6056-9. Epub 2018 Jan 18.
Per oral endoscopic myotomy (POEM) has gained increasing popularity for treating achalasia. A multidisciplinary approach may allow safe and early adoption of POEM into clinical practice.
We performed a retrospective review of our initial POEM cases. All procedures were performed by a team of interventional gastroenterologist and thoracic surgeon. We analyzed demographics, comorbidities, achalasia subtypes, length of hospital stay, duration of surgery, morbidity, mortality, length of myotomy, preoperative and postoperative Eckardt scores.
Thirty-one consecutive patients underwent POEM during the 24-month period from January 2014 to December 2015. Eighteen patients (58%) had prior non-operative interventions. Average duration of follow-up was 9.6 months. Seventeen patients (66.8%) had follow-up of 12 months and longer. Average preoperative Eckardt score was 6.3 (3-10), median 6. Average postoperative Eckardt score was 1.4 (0-8), median 1, in 1 month and an average 2.2, median 1, in 1 year. Patients with type III achalasia were most refractory to treatment, while patients with type II had the best results. Average LOS was 1.3 days (1-5), median 1 day. Average DOS was 106 min (60-148), median 106. Average LOM was 13 cm (10-15), with median of 13 cm. We had one 30-day mortality secondary to coronary artery disease. Four patients had prior Heller myotomies and underwent a posterior myotomy during POEM, with outcomes similar to patients with no prior myotomy.
We demonstrated safety and efficiency of a multispecialty approach for achalasia with POEM with a low rate of complications.
经口内镜下肌切开术(POEM)在治疗贲门失弛缓症方面越来越受欢迎。多学科方法可能允许安全和早期将 POEM 应用于临床实践。
我们对我们最初的 POEM 病例进行了回顾性分析。所有手术均由介入胃肠病学家和胸外科医生团队进行。我们分析了人口统计学、合并症、贲门失弛缓症亚型、住院时间、手术时间、发病率、死亡率、肌切开长度、术前和术后 Eckardt 评分。
在 2014 年 1 月至 2015 年 12 月的 24 个月期间,31 例连续患者接受了 POEM。18 例(58%)患者有非手术干预的既往史。平均随访时间为 9.6 个月。17 例(66.8%)患者的随访时间为 12 个月或更长时间。平均术前 Eckardt 评分为 6.3(3-10),中位数为 6。平均术后 Eckardt 评分为 1.4(0-8),中位数为 1,在 1 个月时,平均为 2.2,中位数为 1,在 1 年时。III 型贲门失弛缓症患者对治疗最具抵抗性,而 II 型贲门失弛缓症患者的结果最好。平均 LOS 为 1.3 天(1-5),中位数为 1 天。平均 DOS 为 106 分钟(60-148),中位数为 106。平均 LOM 为 13cm(10-15),中位数为 13cm。我们有 1 例 30 天死亡率继发于冠状动脉疾病。4 例患者曾行 Heller 肌切开术,在 POEM 期间行后肌切开术,其结果与无既往肌切开术的患者相似。
我们证明了多学科方法治疗贲门失弛缓症的安全性和有效性,POEM 并发症发生率低。