使用固定化酶和CSTR-PFTR循环反应系统对酶法生产葡萄糖酸进行建模与模拟。
Modeling and simulation of enzymatic gluconic acid production using immobilized enzyme and CSTR-PFTR circulation reaction system.
作者信息
Li Can, Lin Jianqun, Gao Ling, Lin Huibin, Lin Jianqiang
机构信息
State Key Laboratory of Microbial Technology, Microbiology Technology Institute, Shandong University, Jinan, 250100, China.
Institute of Information Science and Engineering, School of Information Science and Engineering, Shandong Normal University, Jinan, China.
出版信息
Biotechnol Lett. 2018 Apr;40(4):649-657. doi: 10.1007/s10529-018-2509-4. Epub 2018 Jan 18.
OBJECTIVES
Production of gluconic acid by using immobilized enzyme and continuous stirred tank reactor-plug flow tubular reactor (CSTR-PFTR) circulation reaction system.
RESULTS
A production system is constructed for gluconic acid production, which consists of a continuous stirred tank reactor (CSTR) for pH control and liquid storage and a plug flow tubular reactor (PFTR) filled with immobilized glucose oxidase (GOD) for gluconic acid production. Mathematical model is developed for this production system and simulation is made for the enzymatic reaction process. The pH inhibition effect on GOD is modeled by using a bell-type curve.
CONCLUSIONS
Gluconic acid can be efficiently produced by using the reaction system and the mathematical model developed for this system can simulate and predict the process well.
目的
利用固定化酶和连续搅拌釜式反应器-活塞流管式反应器（CSTR-PFTR）循环反应系统生产葡萄糖酸。
结果
构建了用于葡萄糖酸生产的系统，该系统由用于pH控制和液体储存的连续搅拌釜式反应器（CSTR）以及填充有固定化葡萄糖氧化酶（GOD）用于生产葡萄糖酸的活塞流管式反应器（PFTR）组成。为该生产系统建立了数学模型，并对酶促反应过程进行了模拟。通过钟形曲线对pH对GOD的抑制作用进行了建模。
结论
利用该反应系统可高效生产葡萄糖酸，且为该系统建立的数学模型能很好地模拟和预测该过程。
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