Mitsui Hideki, Nakazawa Tsuyoshi, Tanimura Akira, Karasuno Takahiro, Hiraoka Akira
Department of Hematology/Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Department of Clinical Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-Nakamichi, Higashinari-ku, 537-8511, Osaka, Japan.
Int J Hematol. 2007 Aug;86(2):193-195. doi: 10.1532/IJH97.06162. Epub 2018 Jan 16.
We report a case of donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) occurring after cord blood transplantation (CBT). A 41-year-old man developed precursor B-cell acute lymphoblastic leukemia with a karyotype of 46, XY, t(9;22)(q34;q11) and inv(9)(p11;q13), for which he received CBT from a sex-mismatched donor at the first complete remission of the leukemia. Five months after CBT, gradual neutrophilia of unknown origin developed following the myeloid reconstitution after CBT. Karyotyping of bone marrow cells at 9 months after CBT showed 46,XX, t(7;11)(p15;p15) in 17/20 dividing cells, but neither Philadelphia chromosome (Ph) nor inv(9)(p11;q13) was present. This is the first report of chronic myeloproliferative disease with t(7;11)(p15;p15) that developed in donor cells after CBT. The donor was well-developed and healthy, at least at the time of follow-up, half a year after the birth.
