Takasaki N, Kaneko Y, Maseki N, Sakurai M, Shimamura K, Takayama S
Cancer. 1987 Feb 1;59(3):424-8. doi: 10.1002/1097-0142(19870201)59:3<424::aid-cncr2820590312>3.0.co;2-j.
A case of hemophagocytic syndrome that developed in a patient with T-cell acute lymphoblastic leukemia (ALL) with a novel chromosome translocation involving 14q11 is reported. A 15-year-old boy with T-cell ALL in relapse showed leukemic cells with an abnormal karyotype of 46,XY,-15,t(11;14)(p15;q11), +der(15)t(15;?)(p11;?). Pancytopenia and extensive hemophagocytosis by macrophages in the bone marrow were observed after reinduction chemotherapy and again at the terminal stage. At autopsy, infiltration of such cells was also found in other organs. The findings suggested occurrence of hemophagocytic syndrome probably associated with cytomegalovirus (CMV) infection. The t(11;14)(p15;q11) may be a novel translocation specific for T-cell ALL, and conceivably, the association of T-cell ALL with the histiocytosis in this patient may not have been coincidental.
报告了1例T细胞急性淋巴细胞白血病（ALL）患者发生噬血细胞综合征的病例，该患者伴有涉及14q11的新型染色体易位。一名复发的15岁T细胞ALL男孩的白血病细胞核型异常，为46,XY,-15,t(11;14)(p15;q11), +der(15)t(15;?)(p11;?)。再诱导化疗后以及终末期再次观察到全血细胞减少和骨髓中巨噬细胞广泛噬血现象。尸检时，在其他器官也发现了此类细胞浸润。这些发现提示噬血细胞综合征的发生可能与巨细胞病毒（CMV）感染有关。t(11;14)(p15;q11)可能是T细胞ALL特有的一种新型易位，并且可以想象，该患者中T细胞ALL与组织细胞增多症之间的关联可能并非偶然。
