Bhathena S J, Recant L, Voyles N R, Timmers K I, Reiser S, Smith J C, Powell A S
Am J Clin Nutr. 1986 Jan;43(1):42-6. doi: 10.1093/ajcn/43.1.42.
Twenty-four male subjects participated in a study in which the effect of feeding diets low in copper (1.03 mg/day) on plasma opiates was determined. The subjects were fed a low-copper diet for 11 wk with either starch or fructose as a major source of carbohydrate. Feeding low-copper diet decreased serum copper level significantly. In addition, plasma leu- and met-enkephalins decreased significantly while beta-endorphin levels rose. On repletion with copper (3 mg/day) for 3 wk, plasma enkephalins increased while beta-endorphin levels decreased to pretest values. These results suggest that feeding low copper decreases plasma enkephalins, which may reflect a copper-dependent process affecting enkephalin biosynthesis and/or release.
24名男性受试者参与了一项研究，该研究测定了低铜饮食（1.03毫克/天）对血浆阿片类物质的影响。受试者食用低铜饮食11周，以淀粉或果糖作为碳水化合物的主要来源。食用低铜饮食显著降低了血清铜水平。此外，血浆亮氨酸脑啡肽和甲硫氨酸脑啡肽显著降低，而β-内啡肽水平升高。在补充铜（3毫克/天）3周后，血浆脑啡肽增加，而β-内啡肽水平降至测试前值。这些结果表明，低铜饮食会降低血浆脑啡肽，这可能反映了一个影响脑啡肽生物合成和/或释放的铜依赖性过程。
