Removable Water-Soluble Olefin Metathesis Catalyst via Host-Guest Interaction.

A highly removable N-heterocyclic carbene ligand for a transition-metal catalyst in aqueous media via host-guest interactions has been developed. Water-soluble adamantyl tethered ethylene glycol in the ligand leads a hydrophobic inclusion into the cavity of β-cyclodextrin. Ruthenium (Ru) olefin metathesis catalyst with this ligand demonstrated excellent performance in various metathesis reactions in water as well as in CHCl, and removal of residual Ru was performed via filtration utilizing a host-guest interaction and extraction.