Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Jiangsu Key Laboratory of Food Quality and Safety-State Key Laboratory Cultivation Base of MOST, Institute of Food Safety, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Microbiol Spectr. 2018 Jan;6(1). doi: 10.1128/microbiolspec.ARBA-0005-2017.
Bacteria of the genus are found throughout the environment, in close association with soil, sewage, and plants. , the first member of this genus, is the predominant species, observed in soil, water, plants, animals, and humans. It is also an opportunistic pathogen associated with the increased number of infections in both humans and animals in recent years. In this article, we summarize all species (mainly ) isolated from animals and food products of animal origin and further distinguish all isolates based on antimicrobial susceptibility and resistance phenotypes. The various mechanisms of both intrinsic and acquired antimicrobial resistance, which were mainly identified in isolates of nosocomial infections, have been classified as follows: multidrug efflux pumps; resistance to β-lactams, aminoglycosides, quinolones, trimethoprim-sulfamethoxazole, and phenicols; and alteration of lipopolysaccharide and two-component regulatory systems. The dissemination, coselection, and persistence of resistance determinants among isolates have also been elaborated.
属的细菌存在于环境中，与土壤、污水和植物密切相关。属的第一个成员，是该属中占优势的物种，在土壤、水、植物、动物和人类中都有观察到。它也是一种与近年来人类和动物中越来越多感染相关的机会性病原体。在本文中，我们总结了所有从动物和动物源性食品产品中分离出的种（主要是 ），并进一步根据抗菌药物敏感性和耐药表型区分了所有分离株。主要在医院感染分离株中鉴定出的固有和获得性抗菌药物耐药的各种机制已被分类如下：多药外排泵；对β-内酰胺类、氨基糖苷类、喹诺酮类、甲氧苄啶-磺胺甲恶唑和酚类的耐药性；以及脂多糖和双组分调节系统的改变。还详细阐述了 分离株中耐药决定因素的传播、共选择和持续存在。
