Castillo-Fenoy A, Morice M C, Royer T, Hennetier G
Arch Mal Coeur Vaiss. 1985 Sep;78(9):1384-91.
The long term outcome of patients undergoing aortic valve replacement (AVR) for chronic aortic regurgitation (AR) is mainly determined by the reversibility or permanence of left ventricular dysfunction. We analysed the echocardiogram of 49 patients before and after surgery to identify the patients whose left ventricular dysfunction regressed completely after AVR. The patients were divided into 2 groups according to the results of the last postoperative echocardiogram: Group I: 25 patients whose left ventricular dimensions and wall motion reverted to normal; Group II: 24 patients with dilated and/or hypokinetic left ventricles. The two groups of patients were comparable for sex (Group I: 19 men, 6 women; Group II: 20 men, 4 women), age (Group I: 50,8 years, Group II: 53,9 years) and length of postoperative follow-up (Group I: 32 months, Group II: 34 months). The following parameters were measured and compared: diastolic and systolic left ventricular dimensions, myocardial mass and ventricular wall motion.
Patients in Group I had less left ventricular dilatation than those in Group II (+35% vs +60%, p less than 0,001) and left ventricular contraction was better (FE: 62% vs 45%, p less than 0,001; %FS: 35% vs 23%, p less than 0,001). This study establishes that patients with chronic AR and % delta Dd less than 60%, an EF greater than 50% or %FS greater than 25%, have about a 90% probability of normalisation of LV function after AVR. If one of the indices exceeds these threshold values, the probability of permanent LV dilatation and/or hypokinesia after AVR is also about 90%.(ABSTRACT TRUNCATED AT 250 WORDS)
接受主动脉瓣置换术(AVR)治疗慢性主动脉瓣反流(AR)的患者的长期预后主要取决于左心室功能障碍的可逆性或永久性。我们分析了49例患者手术前后的超声心动图,以确定那些在AVR后左心室功能障碍完全消退的患者。根据术后最后一次超声心动图结果将患者分为两组:第一组:25例左心室大小和壁运动恢复正常的患者;第二组:24例左心室扩张和/或运动减弱的患者。两组患者在性别(第一组:19例男性,6例女性;第二组:20例男性,4例女性)、年龄(第一组:50.8岁,第二组:53.9岁)和术后随访时间(第一组:32个月,第二组:34个月)方面具有可比性。测量并比较了以下参数:左心室舒张和收缩期大小、心肌质量和心室壁运动。
第一组患者的左心室扩张程度低于第二组(分别为+35%和+60%,p<0.001),左心室收缩功能更好(射血分数:62%对45%,p<0.001;短轴缩短率:35%对23%,p<0.001)。本研究表明,慢性AR患者且舒张末期内径变化百分比(% delta Dd)小于60%、射血分数(EF)大于50%或短轴缩短率(%FS)大于25%,在AVR后左心室功能正常化的概率约为90%。如果其中一项指标超过这些阈值,AVR后左心室永久性扩张和/或运动减弱的概率也约为90%。(摘要截断于250字)