Kamei C, Kurokawa K, Tasaka K
Arzneimittelforschung. 1985;35(9):1377-80.
Effects of six dihydropyridine derivatives (nifedipine, nisoldipine, nitrendipine, nicardipine, nimodipine and niludipine) and hydralazine on blood pressure and heart rate in spontaneously hypertensive rats (SHR) were studied in comparison with those in normotensive rats (NR). Nisoldipine, nitrendipine and nicardipine showed stronger hypotensive effect in SHR than in NR. All the dihydropyridine derivatives--especially nifedipine, nitrendipine and niludipine--lowered blood pressure of SHR at doses smaller than those producing positive chronotropic effect. Hydralazine caused hypotensive effect in the same extent both in SHR and in NR and, moreover, it brought about tachycardia at doses smaller than those lowering blood pressure.
研究了六种二氢吡啶衍生物（硝苯地平、尼索地平、尼群地平、尼卡地平、尼莫地平和尼鲁地平）及肼苯哒嗪对自发性高血压大鼠（SHR）血压和心率的影响，并与正常血压大鼠（NR）进行了比较。尼索地平、尼群地平和尼卡地平对SHR的降压作用比对NR的更强。所有二氢吡啶衍生物，尤其是硝苯地平、尼群地平和尼鲁地平，在产生正性变时效应的剂量以下即可降低SHR的血压。肼苯哒嗪对SHR和NR的降压作用程度相同，而且，在低于降压剂量时即可引起心动过速。
