Pruneau D, Roy F
Arzneimittelforschung. 1987 Apr;37(4):416-8.
Effects of two dihydropyridine derivatives, nifedipine and nicardipine, on systolic blood pressure and heart rate in adult (4- to 5-month-old) spontaneously hypertensive rats (SHR) were studied in comparison with those in aged (11- to 12-month-old) SHR. Both calcium channel blockers induced similar dose-dependent hypotensive effects in 4- to 5-month- and 11- to 12-month-old SHR. The maximal hypotensive action of both calcium channel blockers was delayed in aged SHR compared to adult SHR. Nicardipine induced a similar reflex tachycardia in adult and aged SHR. In contrast to nicardipine there was no increase in heart rate after administration of nifedipine in aged SHR at same hypotensive effects. It is concluded that nifedipine and nicardipine are potent antihypertensive agents in aged SHR which differently affect heart rate.
研究了两种二氢吡啶衍生物硝苯地平和尼卡地平对成年（4至5月龄）自发性高血压大鼠（SHR）收缩压和心率的影响，并与老年（11至12月龄）SHR进行了比较。两种钙通道阻滞剂在4至5月龄和11至12月龄的SHR中均诱导出相似的剂量依赖性降压作用。与成年SHR相比，老年SHR中两种钙通道阻滞剂的最大降压作用延迟出现。尼卡地平在成年和老年SHR中诱导出相似的反射性心动过速。与尼卡地平相反，在老年SHR中给予硝苯地平产生相同降压效果后心率没有增加。得出的结论是，硝苯地平和尼卡地平是老年SHR中的强效抗高血压药物，但对心率的影响不同。
