PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Centre for Neuroscience, IISC Bangalore, India.
Cell Death Dis. 2018 Jan 19;9(2):65. doi: 10.1038/s41419-017-0101-9.
Cell division and differentiation are two fundamental physiological processes that need to be tightly balanced to achieve harmonious development of an organ or a tissue without jeopardizing its homeostasis. The role played by the centriolar protein STIL is highly illustrative of this balance at different stages of life as deregulation of the human STIL gene expression has been associated with either insufficient brain development (primary microcephaly) or cancer, two conditions resulting from perturbations in cell cycle and chromosomal segregation. This review describes the recent advances on STIL functions in the control of centriole duplication and mitotic spindle integrity, and discusses how pathological perturbations of its finely tuned expression result in chromosomal instability in both embryonic and postnatal situations, highlighting the concept that common key factors are involved in developmental steps and tissue homeostasis.
细胞分裂和分化是两个基本的生理过程，需要紧密平衡，以实现器官或组织的和谐发育，而不会危及内稳态。中心体蛋白 STIL 的作用很好地说明了这种平衡在生命的不同阶段的表现，因为人类 STIL 基因表达的失调与脑发育不足（原发性小头畸形）或癌症有关，这两种情况都是由于细胞周期和染色体分离的干扰而导致的。这篇综述描述了 STIL 在控制中心体复制和有丝分裂纺锤体完整性方面的最新进展，并讨论了其精细表达的病理扰动如何导致胚胎和产后情况下的染色体不稳定性，强调了在发育步骤和组织内稳态中涉及共同关键因素的概念。
