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[0.1%洗必泰漱口水意外中心静脉给药]

[Accidental central venous administation of 0.1 % chlorhexidine mouthwash].

作者信息

Ploner M, Löffel L M, Schüpfer G, Besmer I, Konrad C J

机构信息

Klinik für Anästhesie, Rettungsmedizin und Schmerztherapie, Kantonsspital Luzern, Luzern 16, Luzern, Schweiz.

Universitätsklinik für Anästhesiologie und Schmerztherapie, Inselspital, Freiburgstrasse, 3010, Bern, Schweiz.

出版信息

Anaesthesist. 2018 Mar;67(3):204-208. doi: 10.1007/s00101-018-0408-7. Epub 2018 Jan 19.

DOI:10.1007/s00101-018-0408-7
PMID:29352364
Abstract

Medication errors are frequent and a serious safety concern. Chlorhexidine (CHX) is used daily in healthcare as a disinfectant. Its accidental intravascular injection is scarcely described. Serious complications, such as acute respiratory distress syndrome (ARDS) could be a consequence. We describe a case of central venous administration of 0.1% CHX mouthwash, its potential complications and possibilities of treatment. In contrast to another case report our patient had no detectable adverse side effects. The immediate hemofiltration and cleansing of the i. v. line may have contributed to this favorable outcome.

摘要

用药错误很常见,是一个严重的安全问题。洗必泰(CHX)在医疗保健中每天用作消毒剂。其意外血管内注射的情况鲜有描述。严重并发症,如急性呼吸窘迫综合征(ARDS)可能是其后果。我们描述了一例0.1%CHX漱口水经中心静脉给药的病例、其潜在并发症及治疗方法。与另一例病例报告不同的是,我们的患者没有可检测到的不良副作用。即时血液滤过和静脉管路清洗可能促成了这一良好结果。

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Severe adhesive arachnoiditis resulting in progressive paraplegia following obstetric spinal anaesthesia: a case report and review.产科脊髓麻醉后严重粘连性蛛网膜炎导致进行性截瘫:病例报告及文献复习。
Anaesthesia. 2012 Dec;67(12):1386-94. doi: 10.1111/anae.12017. Epub 2012 Oct 12.
2
Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis.口腔抗菌剂预防呼吸机相关性肺炎的系统评价和荟萃分析。
Lancet Infect Dis. 2011 Nov;11(11):845-54. doi: 10.1016/S1473-3099(11)70127-X. Epub 2011 Jul 26.
3
Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats.
常用消毒剂和表面活性剂经口服和血管内给药对大鼠的毒性作用比较研究。
J Appl Toxicol. 2012 Jul;32(7):480-7. doi: 10.1002/jat.1662. Epub 2011 Mar 9.
4
Errors in administration of parenteral drugs in intensive care units: multinational prospective study.重症监护病房肠外用药管理中的差错:多国前瞻性研究。
BMJ. 2009 Mar 12;338:b814. doi: 10.1136/bmj.b814.
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Chlorhexidine--pharmacology and clinical applications.洗必泰——药理学与临床应用
Anaesth Intensive Care. 2008 Jul;36(4):502-12. doi: 10.1177/0310057X0803600404.
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Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery.0.12%葡萄糖酸氯己定口腔含漱液对降低心脏手术患者医院获得性肺炎患病率的有效性。
Am J Crit Care. 2002 Nov;11(6):567-70.
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Dialysis and hemoperfusion in poisoning.中毒时的透析与血液灌流
Adv Ren Replace Ther. 2002 Jan;9(1):26-30. doi: 10.1053/jarr.2002.30470.
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The frequency and nature of drug administration error during anaesthesia.麻醉期间用药错误的频率及性质。
Anaesth Intensive Care. 2001 Oct;29(5):494-500. doi: 10.1177/0310057X0102900508.
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J Toxicol Clin Toxicol. 2001;39(1):77-80. doi: 10.1081/clt-100102884.