Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.
J Arthroplasty. 2018 May;33(5):1467-1471. doi: 10.1016/j.arth.2017.12.030. Epub 2017 Dec 29.
Pigmented villonodular synovitis (PVNS) is a rare, benign, painful proliferation of the synovium previously treated successfully with total hip arthroplasty (THA). Published results come from small series; therefore, the purpose of this study is to investigate the outcomes of THA in the setting of PVNS.
We identified 25 patients with histologically confirmed, diffuse PVNS who underwent THA between 1971 and 2013. Mean follow-up and age was 10 years and 39 years. Before arthroplasty, 16 patients (64%) had at least 1 surgical procedure (mean, 1; range, 1-3) to treat PVNS. Twenty (80%) patients had "active" disease and underwent synovectomy. No constrained acetabular components were used.
The 10-year disease free-survival was 100%. Recurrence occurred in 1 patient at 24 years postoperatively. Nineteen patients (76%) sustained a complication (most commonly component loosening (n = 12 [48%]), and 16 required revision surgery. The 10-year revision-free survival was 66% for conventional polyethylene implants and 100% for highly cross-linked polyethylene devices. Mean Harris Hip Score improved significantly from 48 (range, 23-69) preoperatively to 78 (range, 47-96) postoperatively (P < .001).
THA in the setting of PVNS improves patient function with a low rate of local recurrence. Complication and revision rates are high in this series likely owing to the young and active patient population and the use of conventional polyethylene. Modern bearings theoretically reduce the risk of revision.
色素沉着绒毛结节性滑膜炎(PVNS)是一种罕见的良性、疼痛性滑膜增生,此前曾成功通过全髋关节置换术(THA)进行治疗。已发表的研究结果来自于小样本系列研究;因此,本研究旨在探讨在 PVNS 背景下 THA 的治疗效果。
我们共纳入了 25 例经组织学证实的弥漫性 PVNS 患者,这些患者均于 1971 年至 2013 年间接受了 THA。平均随访时间和年龄分别为 10 年和 39 岁。在进行关节置换术前,16 例(64%)患者至少接受过 1 次(平均 1 次,范围 1-3 次)用于治疗 PVNS 的手术。20 例(80%)患者存在“活跃”疾病,行滑膜切除术。未使用约束性髋臼组件。
10 年无疾病生存率为 100%。1 例患者在术后 24 年复发。19 例(76%)患者发生并发症(最常见的是假体松动(12 例[48%]),16 例患者需要进行翻修手术。常规聚乙烯假体的 10 年翻修生存率为 66%,而高交联聚乙烯假体的 10 年翻修生存率为 100%。术前 Harris 髋关节评分为 48(范围,23-69),术后显著提高至 78(范围,47-96)(P <.001)。
在 PVNS 背景下进行 THA 可改善患者的功能,局部复发率较低。在本研究系列中,并发症和翻修率较高,这可能与患者人群较为年轻且活跃以及常规聚乙烯的使用有关。现代的关节轴承理论上降低了翻修的风险。