Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
College of Pharmacy, Ajou University, Suwon, Gyunggido, South Korea.
Clin Exp Rheumatol. 2018 Jul-Aug;36(4):533-539. Epub 2018 Jan 15.
Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) has been reported to have pro-inflammatory properties. The aim of this study was to evaluate the clinical significance of serum AIMP1 in patients with systemic lupus erythematosus (SLE).
Serum levels of AIMP1 were measured in 160 patients with SLE using a human AIMP1 ELISA kit. Eighty patients were classified as active SLE (SLEDAI-2K ≥ 5), and 80 patients were classified as stable SLE. Correlation between serum AIMP1, SLE disease activity index-2000 (SLEDAI-2K), and laboratory variables related to disease activity or inflammatory burdens were assessed using Pearson's correlation analysis. The optimal cut-off value for serum AIMP1 to predict active SLE was estimated by using a receiver operator characteristic curve, and logistic regression analysis was used to compare the odds ratios (ORs) of laboratory variables in predicting active SLE.
The median serum AIMP1 was higher in patients with active SLE than those with stable SLE (8.0 vs. 6.5 ng/ml, p<0.001). Serum AIMP1 demonstrated correlation with SLEDAI-2K and laboratory variables related to disease activity or inflammatory burdens. The optimal cut-off AIMP1 to predict active SLE was 10.09. Multivariate logistic regression analysis including conventional laboratory variables demonstrated that serum AIMP1 ≥10.09 ng/ml (OR 3.919, 95% confidence interval 1.223-12.564, p=0.022) was useful in predicting active SLE.
Serum levels of AIMP1 were associated with disease activity of SLE and could predict active SLE based on SLEDAI-2K.
已报道分泌型氨酰-tRNA 合成酶相互作用多功能蛋白-1（AIMP1）具有促炎特性。本研究旨在评估血清 AIMP1 在系统性红斑狼疮（SLE）患者中的临床意义。
使用人 AIMP1 ELISA 试剂盒检测 160 例 SLE 患者的血清 AIMP1 水平。80 例患者被归类为活动期 SLE（SLEDAI-2K≥5），80 例患者被归类为稳定期 SLE。采用 Pearson 相关分析评估血清 AIMP1 与 SLE 疾病活动指数-2000（SLEDAI-2K）以及与疾病活动或炎症负担相关的实验室变量之间的相关性。采用受试者工作特征曲线估计血清 AIMP1 预测活动期 SLE 的最佳截断值，并采用逻辑回归分析比较预测活动期 SLE 的实验室变量的优势比（OR）。
活动期 SLE 患者的血清 AIMP1 中位数高于稳定期 SLE 患者（8.0 与 6.5ng/ml，p<0.001）。血清 AIMP1 与 SLEDAI-2K 以及与疾病活动或炎症负担相关的实验室变量相关。预测活动期 SLE 的最佳 AIMP1 截断值为 10.09。包括常规实验室变量在内的多变量逻辑回归分析表明，血清 AIMP1≥10.09ng/ml（OR 3.919，95%置信区间 1.223-12.564，p=0.022）可用于预测活动期 SLE。
血清 AIMP1 水平与 SLE 的疾病活动度相关，可基于 SLEDAI-2K 预测活动期 SLE。
