Korčok Davor Jovan, Tršić-Milanović Nada Aleksandar, Ivanović Nevena Djuro, Đorđević Brižita Ivan
Department of Research and Development Abela Pharm.
Department of Bromatology, Faculty of Pharmacy, University of Belgrade.
Chem Pharm Bull (Tokyo). 2018 Apr 1;66(4):347-352. doi: 10.1248/cpb.c17-00634. Epub 2018 Jan 19.
Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron and vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.
益生菌作为功能性食品以及具有多种作用水平且有助于人类健康的药物制剂，越来越多地出现。益生菌通过适当的剂量，并在保质期内维持宣称的益生菌细胞数量来实现其积极效果。开发益生菌产品的重要前提是正确选择经临床验证的益生菌菌株、选择其他活性成分，以及优化每产品剂量中益生菌活性成分的数量。本科学论文描述了含有益生菌植物乳杆菌299v、铁和维生素C的膳食补充剂配方中益生菌细胞数量的优化。在归类为膳食补充剂的胶囊化益生菌产品的开发批次中，分析了活性成分数量的变化，该产品含有以下成分：益生菌培养物、铁的蔗糖体形式和维生素C。选择了50毫克植物乳杆菌活性成分的最佳数量。本科学论文的目的是选择含有铁和维生素C的膳食补充剂中益生菌培养物的最佳配方，并通过分析活益生菌细胞数量来确定其保质期。
