嵌合体网格在狭窄管道内细胞运动和聚集建模中的应用。
Application of Chimera grid to modelling cell motion and aggregation in a narrow tube.
作者信息
Chung B, Johnson P C, Popel A S
机构信息
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, U.S.A.
出版信息
Int J Numer Methods Fluids. 2007 Jan 10;53(1):105-128. doi: 10.1002/fld.1251. Epub 2006 Jun 19.
A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.
提出了一种使用嵌合体网格方法的计算方案，用于模拟狭窄管中两个红细胞（RBC）的三维运动和聚集。细胞被建模为刚性椭球形颗粒；该计算方案适用于充满流体的可变形颗粒。两个红细胞之间的吸引力通过耗竭相互作用理论建模，并用于模拟两个细胞的聚集。通过模拟，我们表明嵌合体网格方法适用于模拟微血管和微血管网络中多个红细胞的三维运动和聚集。
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