Jaschke W, Lipton M J, Boyd D, Moss A A, Cann C, Goldberg H I, Margulis A R, Sievers R
Eur J Radiol. 1985 Nov;5(4):256-60.
Seven adult male mongrel dogs were monitored by electromagnetic flow probes and string occluders around the hepatic artery and portal vein. Then, time density curves of the liver, aorta and portal vein were recorded using dynamic CT scanning following the bolus injection of contrast material into a peripheral vein (n = 7) and a mesenteric vein branch (n = 5). Information on total hepatic blood flow could not be obtained from the mesenteric vein injection. The hepatic time density curve could, however, be broken into its two components, hepatic arterial and portal venous flow contribution, by selective ligation of the hepatic artery or portal vein. It could be demonstrated that the arterial component of liver enhancement reached its peak at the end of the aortic wash-out of contrast material. Thus, the hepatic time-density curve could be broken in its two components by superimposing the aortic time density curve onto the hepatic curve. An attempt was made to estimate relative portal venous blood flow by using the slopes or the peaks of both components of the hepatic curve. Using the slopes of the hepatic curve resulted in a consistent underestimation of portal venous blood flow, whereas the peaks gave an estimate of portal venous flow with an accuracy within +/- 8%.
七只成年雄性杂种犬通过电磁流量探头以及环绕肝动脉和门静脉的线栓进行监测。然后，在将造影剂经外周静脉推注（n = 7）和经肠系膜静脉分支推注（n = 5）后，使用动态CT扫描记录肝脏、主动脉和门静脉的时间密度曲线。从肠系膜静脉注射无法获取肝总血流量的信息。然而，通过选择性结扎肝动脉或门静脉，肝脏时间密度曲线可分解为其两个组成部分，即肝动脉血流贡献和门静脉血流贡献。可以证明，肝脏强化的动脉成分在造影剂从主动脉清除结束时达到峰值。因此，通过将主动脉时间密度曲线叠加到肝脏曲线上，肝脏时间密度曲线可分解为其两个组成部分。尝试通过使用肝脏曲线两个组成部分的斜率或峰值来估计门静脉相对血流量。使用肝脏曲线的斜率会导致门静脉血流量持续低估，而使用峰值估计门静脉血流量的准确度在±8%以内。
