Department of Radiology, First Affiliated Hospital of Dalian Medical University, Liaoning 116011, China.
Korean J Radiol. 2018 Jan-Feb;19(1):130-138. doi: 10.3348/kjr.2018.19.1.130. Epub 2018 Jan 2.
To exploit material decomposition analysis in dual-energy spectral computed tomography (CT) to assess the blood supply status of the ground-glass opacity (GGO) in lungs.
This retrospective study included 48 patients with lung adenocarcinoma, who underwent a contrast-enhanced dual-energy spectral CT scan before treatment (53 GGOs in total). The iodine concentration (IC) and water content (WC) of the GGO, the contralateral and ipsilateral normal lung tissues were measured in the arterial phase (AP) and their differences were analyzed. IC, normalized IC (NIC), and WC values were compared between the pure ground-glass opacity (pGGO) and the mixed ground-glass opacity (mGGO), and between the group of preinvasive lesions and the minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA) groups.
The values of pGGO (IC = 20.9 ± 6.2 mg/mL and WC = 345.1 ± 87.1 mg/mL) and mGGO (IC = 23.8 ± 8.3 mg/mL and WC = 606.8 ± 124.5 mg/mL) in the AP were significantly higher than those of the contralateral normal lung tissues (IC = 15.0 ± 4.9 mg/mL and WC = 156.4 ± 36.8 mg/mL; IC = 16.2 ± 5.7 mg/mL and WC = 169.4 ± 41.0 mg/mL) and ipsilateral normal lung tissues (IC = 15.1 ± 6.2 mg/mL and WC = 156.3 ± 38.8 mg/mL; IC = 15.9 ± 6.0 mg/mL and WC = 174.7 ± 39.2 mg/mL; all < 0.001). After normalizing the data according to the values of the artery, pGGO (NIC = 0.1 and WC = 345.1 ± 87.1 mg/mL) and mGGO (NIC = 0.2 and WC = 606.8 ± 124.5 mg/mL) were statistically different ( = 0.049 and < 0.001, respectively), but not for the IC value ( = 0.161). The WC values of the group with preinvasive lesions and MIA (345.4 ± 96.1 mg/mL) and IA (550.1 ± 158.2 mg/mL) were statistically different ( < 0.001).
Using dual-energy spectral CT and material decomposition analysis, the IC in GGO can be quantitatively measured which can be an indicator of the blood supply status in the GGO.
利用双能量光谱 CT 中的物质分解分析来评估肺部磨玻璃密度（GGO）的血液供应状态。
本回顾性研究纳入了 48 例肺腺癌患者，这些患者在治疗前均接受了增强双能光谱 CT 扫描（共 53 个 GGO）。在动脉期（AP）测量 GGO、对侧及同侧正常肺组织的碘浓度（IC）和水含量（WC），并分析其差异。比较纯磨玻璃密度（pGGO）和混合磨玻璃密度（mGGO）、以及术前病变组、微浸润性腺癌（MIA）和浸润性腺癌（IA）组之间的 IC、归一化 IC（NIC）和 WC 值。
AP 中 pGGO（IC=20.9±6.2mg/mL 和 WC=345.1±87.1mg/mL）和 mGGO（IC=23.8±8.3mg/mL 和 WC=606.8±124.5mg/mL）的值明显高于对侧正常肺组织（IC=15.0±4.9mg/mL 和 WC=156.4±36.8mg/mL；IC=16.2±5.7mg/mL 和 WC=169.4±41.0mg/mL）和同侧正常肺组织（IC=15.1±6.2mg/mL 和 WC=156.3±38.8mg/mL；IC=15.9±6.0mg/mL 和 WC=174.7±39.2mg/mL；均 <0.001）。根据动脉值对数据进行归一化后，pGGO（NIC=0.1 和 WC=345.1±87.1mg/mL）和 mGGO（NIC=0.2 和 WC=606.8±124.5mg/mL）在统计学上存在差异（=0.049 和 <0.001），但 IC 值无统计学差异（=0.161）。术前病变和 MIA（345.4±96.1mg/mL）及 IA（550.1±158.2mg/mL）组的 WC 值存在统计学差异（<0.001）。
使用双能光谱 CT 和物质分解分析，可以定量测量 GGO 中的 IC，其可能成为 GGO 中血液供应状态的指标。
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