Fusi-Rubiano William J, Yang Yit C, Smallwood Andrew F, Chavan Randhir C, Khogali Saib, Narendran Nirodhini, Cotton James M
Department of Ophthalmology, New Cross Hospital, WV10 0QP, Wolverhampton, UK.
School of Life and Health Sciences, Aston University, B4 7ET, Birmingham, UK.
BMJ Open Ophthalmol. 2017 Jul 5;1(1):e000033. doi: 10.1136/bmjophth-2016-000033. eCollection 2017.
Transcatheter aortic valve implantation (TAVI) is an established treatment for patients with severe symptomatic aortic stenosis. It has a cerebrovascular accident rate of about 5% but the effect on retinal embolic events has not been previously reported. This study investigated the occurrence of retinal emboli following TAVI.
In this prospective observational study, 20 patients underwent full ophthalmic examination to assess retinal embolic events prior to TAVI and at 48 hours and 1 month post-TAVI.
At 48 hours post-TAVI, one patient had a new cotton wool spot in the right eye. At 1 month, another two patients had new retinal emboli events in at least one eye and a fourth patient developed retinal splinter haemorrhages in the right eye.
Retinal embolic events and new retinal abnormalities following TAVI occurred in 15% and 20% of our cohort, respectively, without any associated retinal damage or significant visual problems. Retinal evaluation may be a useful surrogate test for cerebral embolisation in future studies assessing the utility of new valve prostheses and embolic protection devices.
经导管主动脉瓣植入术(TAVI)是重度症状性主动脉瓣狭窄患者的既定治疗方法。其脑血管意外发生率约为5%,但此前尚未报道其对视网膜栓塞事件的影响。本研究调查了TAVI术后视网膜栓子的发生情况。
在这项前瞻性观察研究中,20例患者在TAVI术前、术后48小时和1个月接受了全面的眼科检查,以评估视网膜栓塞事件。
TAVI术后48小时,1例患者右眼出现新的棉絮斑。术后1个月,另外2例患者至少一只眼睛出现新的视网膜栓塞事件,第4例患者右眼出现视网膜片状出血。
在我们的队列中,TAVI术后视网膜栓塞事件和新的视网膜异常分别发生在15%和20%的患者中,且无任何相关的视网膜损伤或严重视力问题。在未来评估新型瓣膜假体和栓塞保护装置效用的研究中,视网膜评估可能是一种用于脑栓塞的有用替代检测方法。