State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Nat Prod Rep. 2018 Jan 25;35(1):75-104. doi: 10.1039/c7np00043j.
Covering: 2011 to July 2017.Spiroketal (spiroacetal), a common moiety in numerous natural products, drugs and functional molecules, has been a central topic in organic chemistry for a long time. Owing to their structural diversity, important bioactivity and functional irreplaceability, natural spiroketals have attracted the interest of natural product chemists, medical chemists, biological chemists, agricultural chemists, synthetic chemists, and chemical biologists. In this review, we focus on the overview of the isolation, bioactivity, biosynthesis and total synthesis of spiroketals from 2011 to July 2017.
2011 年至 2017 年 7 月。螺缩酮（螺缩醛）是许多天然产物、药物和功能分子中的常见部分，长期以来一直是有机化学的一个核心主题。由于其结构多样性、重要的生物活性和功能不可替代性，天然螺缩酮引起了天然产物化学家、药物化学家、生物化学家、农业化学家、合成化学家以及化学生物学家的兴趣。在本综述中，我们重点介绍了 2011 年至 2017 年 7 月期间从螺缩酮的分离、生物活性、生物合成和全合成方面的概述。
