Recent progress in the isolation, bioactivity, biosynthesis, and total synthesis of natural spiroketals.

Covering: 2011 to July 2017.Spiroketal (spiroacetal), a common moiety in numerous natural products, drugs and functional molecules, has been a central topic in organic chemistry for a long time. Owing to their structural diversity, important bioactivity and functional irreplaceability, natural spiroketals have attracted the interest of natural product chemists, medical chemists, biological chemists, agricultural chemists, synthetic chemists, and chemical biologists. In this review, we focus on the overview of the isolation, bioactivity, biosynthesis and total synthesis of spiroketals from 2011 to July 2017.