School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Org Biomol Chem. 2019 Sep 28;17(36):8272-8307. doi: 10.1039/c9ob01598a. Epub 2019 Sep 3.
The spiroketal moiety is an important privileged scaffold that occurs extensively in natural products, drugs, and bioactive molecules. Naturally occurring spiroketals are numerous, however aryl-fused spiroketals are relatively rare. The only comprehensive review disclosing the isolation, biological activity, and synthesis of benzannulated spiroketal natural products was published nearly a decade ago. This review will serve as an update of the 2009 review and include all known families of benzannulated spiroketals, detailing their isolation and biological activity where relevant. Although not exhaustive, endeavours towards their total synthesis will be discussed.
螺缩酮部分是一种重要的特权支架，广泛存在于天然产物、药物和生物活性分子中。天然存在的螺缩酮数量众多，但芳基稠合的螺缩酮相对较少。唯一全面披露苯并稠合螺缩酮天然产物的分离、生物活性和合成的综述是在近十年前发表的。本综述将作为 2009 年综述的更新，包括所有已知的苯并稠合螺缩酮家族，详细介绍它们的分离和相关的生物活性。虽然不是详尽无遗，但将讨论它们的全合成努力。
