Department of Clinical and Experimental Medicine and University Hospital, University of Pisa, via Paradisa 2, 56121, Pisa, Italy.
Diabetologia. 2018 Apr;61(4):770-774. doi: 10.1007/s00125-018-4546-x. Epub 2018 Jan 21.
Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of Diabetologia, Kusmartseva et al ( https://doi.org/10.1007/s00125-017-4494-x ) provide further evidence to support the use of organ donor pancreases for the study of human diabetes. They show that length of terminal hospitalisation of organ donors prior to death does not seem to influence the frequency of inflammatory cells infiltrating the pancreas and the replication of beta cells. These findings are reassuring, demonstrating the reliability of this precious and valuable resource for human islet cells research.
直接在体评估胰岛细胞以研究人类糖尿病的病理生理学受到解剖学和技术障碍的阻碍。迄今为止，大多数已产生的信息都来自于尸检、手术、活体活检或器官捐献获得的胰腺组织的组织学研究。每种方法都有其优点和缺点（如本评论所述）；然而，在本期的《糖尿病学》中，Kusmartseva 等人（https://doi.org/10.1007/s00125-017-4494-x）提供了进一步的证据支持使用器官捐献者的胰腺来研究人类糖尿病。他们表明，器官捐献者在死亡前的住院时间长短似乎不会影响浸润胰腺的炎症细胞的频率和β细胞的复制。这些发现令人安心，证明了这种宝贵资源用于人类胰岛细胞研究的可靠性。
