Gao Yan, Chen Rui, Liang Fengxia
College of Acupuncture-Moxibustion and Orthopaedics of Hubei University of CM, Preventive Treatment of Acupuncture and Moxibustion of Hubei Provincial Collaborative Innovation Center, Wuhan 430061, China.
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology.
Zhongguo Zhen Jiu. 2018 Jan 12;38(1):109-13. doi: 10.13703/j.0255-2930.2018.01.028.
Literature regarding the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the mechanisms of acupuncture for NAFLD published between January of 2006 to December of 2016 was searched in CBM database, Wanfang database, CNKI database and PubMed. After analysis, the possible mechanisms of acupuncture for NAFLD were summarized from 5 following aspects: acupuncture regulating lipid metabolism and participating lipid metabolism-related signaling pathways, acupuncture improving insulin resistance, acupuncture increasing the antioxidant levels of liver tissue to improve lipid peroxidation, acupuncture inhabiting the expression of inflammatory cytokines, and acupuncture improving the morphology and structure of hepatocyte. Based on the characteristics of acupuncture, the suggestions and prospects of future research were proposed from the 4 following aspects: the specificity and compatibility of acupoint, the treatment timing of acupuncture, the stimulus parameter of acupuncture, and the intervention of acupuncture combined with dietary control.
检索了中国生物医学文献数据库(CBM)、万方数据库、中国知网(CNKI)数据库和PubMed中2006年1月至2016年12月发表的关于非酒精性脂肪性肝病(NAFLD)发病机制及针刺治疗NAFLD机制的文献。经分析,从以下5个方面总结了针刺治疗NAFLD的可能机制:针刺调节脂质代谢并参与脂质代谢相关信号通路、针刺改善胰岛素抵抗、针刺提高肝组织抗氧化水平以改善脂质过氧化、针刺抑制炎性细胞因子表达、针刺改善肝细胞形态和结构。基于针刺的特点,从以下4个方面提出了未来研究的建议和展望:穴位的特异性与配伍、针刺治疗时机、针刺刺激参数、针刺联合饮食控制的干预。