Jiang Renjian, Zou Yu
Chongqing TCM Hospital, Chongqing 400021, China.
Zhongguo Zhen Jiu. 2017 Nov 12;37(11):1169-72. doi: 10.13703/j.0255-2930.2017.11.008.
To observe the effects of autologous blood injection and 0.9% NaCl at Zusanli (ST 36) on ovarian function in patients with primary ovarian insufficiency.
Sixty patients with primary ovarian insufficiency were randomly divided into an observation group and a control group, 30 cases in each one. The patients in the observation group were treated with injection of autologous blood at Zusanli (ST 36); the patients in the control group were treated with 0.9% NaCl with identical volume at Zusanli (ST 36). Both the treatments were given once a week for 3 months. The ovarian function, including follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E) were tested before treatment, 1 month, 2 months and 3 months after first acupoint injection; the endometrial thickness before and after treatment and clinical efficacy were compared in the two groups.
Compared before treatment, FSH was lowered in the observation group after 1-month treatment (<0.05), while FSH and LH were lowered and E was increased after 2-month treatment and 3-month treatment (all <0.05). Compared with 1-month treatment, FSH and LH were lowered and E was increased in the observation group after 2-month treatment and 3-month treatment (all <0.05). Compared with 2-month treatment, FSH was lowered and E was increased in the observation group after 3-month treatment (both <0.05). The differences of all serum tests before and after treatment were insignificant in the control group (all >0.05). The FSH after 1-month treatment, and FSH, LH and E after 2-month treatment and 3-month treatment in the observation group were significantly different from those in the control group (all <0.05). The endometrial thickness after treatment in the observation group was higher than that before treatment (<0.05), while the endometrial thickness after treatment in the control group was similar to that before treatment (>0.05); the difference of endometrial thickness before and after treatment in the observation group was higher than that in the control group (<0.05). The clinical effective rate was 83.3% (25/30) in the observation group, which was superior to 46.7% (14/30) in the control group (<0.05).
The autologous blood injection at Zusanli (ST 36) can significantly improve ovarian function, promote endometrial growth in patients with primary ovarian insufficiency.
观察足三里穴（ST 36）注射自体血和0.9%氯化钠对原发性卵巢功能不全患者卵巢功能的影响。
将60例原发性卵巢功能不全患者随机分为观察组和对照组，每组30例。观察组患者于足三里穴（ST 36）注射自体血；对照组患者于足三里穴（ST 36）注射相同体积的0.9%氯化钠。两种治疗均每周进行1次，共3个月。在首次穴位注射前、注射后1个月、2个月和3个月检测卵巢功能，包括卵泡刺激素（FSH）、黄体生成素（LH）和雌二醇（E）；比较两组治疗前后的子宫内膜厚度及临床疗效。
与治疗前比较，观察组治疗1个月后FSH降低（<0.05），治疗2个月和3个月后FSH和LH降低，E升高（均<0.05）。与治疗1个月比较，观察组治疗2个月和3个月后FSH和LH降低，E升高（均<0.05）。与治疗2个月比较，观察组治疗3个月后FSH降低，E升高（均<0.05）。对照组治疗前后各项血清学检测差异均无统计学意义（均>0.05）。观察组治疗1个月后的FSH，治疗2个月和3个月后的FSH、LH和E与对照组比较，差异均有统计学意义（均<0.05）。观察组治疗后的子宫内膜厚度高于治疗前（<0.05），而对照组治疗后的子宫内膜厚度与治疗前相似（>0.05）；观察组治疗前后子宫内膜厚度差值高于对照组（<0.05）。观察组临床有效率为83.3%（25/30），优于对照组的46.7%（14/30）（<0.05）。
足三里穴（ST 36）注射自体血可显著改善原发性卵巢功能不全患者的卵巢功能，促进子宫内膜生长。
