Pei Wenya, Lin Shiyu, Zeng Jingchun, Qian Guifeng, Lin Lizhu, Lin Guohua
Rehabilitation Center, the First Affiliated Hospital of Guangzhou University of CM, Guangzhou 510405, Guangdong Province, China.
Guangzhou University of CM.
Zhongguo Zhen Jiu. 2017 Nov 12;37(11):1191-5. doi: 10.13703/j.0255-2930.2017.11.014.
To observe the effect difference between fire needle combined with chemotherapy and fire needle on quality of life in patients with chemotherapy of non-small cell lung cancer (NSCLC).
With randomized controlled method, a total of 60 patients with chemotherapy of NSCLC were divided into an observation group (fire-needle plus chemotherapy group) and a control group (chemotherapy group), 30 cases in each one. The observation group was treated with fire needle at points which consisted of Geshu (BL 17) and Danshu (BL 19), combined with chemotherapy selected from TP (paclitaxel+cisplatin)/GP (gemcitabine+cisplatin)/DP (docetaxel+cisplatin)/NP (vinorelbine+cisplatin) by the oncologist according to patients' condition. The fire needle was given once a day for 7 days, and chemotherapy was given for 21 days. The control group was treated with chemotherapy alone for 21 days. Before and after treatment, response evaluation criteria in solid tumors (RECIST) was applied for evaluation, and Karnofsky performance status (KPS) and functional assessment of cancer therapy-lung (FACT-L) were applied for evaluation of quality of life in patients with chemotherapy of NSCLC.
The effective rate was 20.0% (6/30) and the stability rate was 73.3% (22/30) in the observation group, which were insignificantly higher than 16.7% (5/30) and 63.3% (19/30) in the control group, respectively (both >0.05). The KPS after treatment was lower than that before treatment in the control group (<0.05); the KPS after treatment was similar to that before treatment in the observation group (>0.05); the KPS in the observation group after treatment was higher than that in the control group (<0.05). The total score and each item score of FACT-L after treatment were higher than those before treatment in the observation group (all <0.05); the physical score and emotional score of FACT-L after treatment were higher than those before treatment in the control group (both <0.05); the total score, physical score, functional score and subscale score in the observation group were significantly higher than those in the control group after treatment (all <0.05), while the social/family score and emotional score in the observation group were insignificantly higher than those in the control group (both >0.05). The differences of KPS total score before and after treatment in the two groups had moderate positive correlation with differences of FACT-L total score (<0.01).
Fire needle can improve quality of life in patients of NSCLC chemotherapy.
观察火针联合化疗与单纯火针对非小细胞肺癌（NSCLC）化疗患者生活质量的影响差异。
采用随机对照法，将60例NSCLC化疗患者分为观察组（火针加化疗组）和对照组（化疗组），每组30例。观察组选取膈俞（BL 17）、肝俞（BL 19）穴位行火针治疗，并由肿瘤专科医生根据患者病情从TP（紫杉醇+顺铂）/GP（吉西他滨+顺铂）/DP（多西他赛+顺铂）/NP（长春瑞滨+顺铂）方案中选择化疗方案。火针每日1次，连续7天，化疗周期为21天。对照组单纯化疗21天。治疗前后采用实体瘤疗效评价标准（RECIST）进行疗效评价，采用卡氏功能状态评分（KPS）及肺癌患者生活质量功能评价量表（FACT-L）对NSCLC化疗患者生活质量进行评价。
观察组有效率为20.0%（6/30），稳定率为73.3%（22/30），分别略高于对照组的16.7%（5/30）和63.3%（19/30），差异均无统计学意义（均>0.05）。对照组治疗后KPS评分低于治疗前（<0.05）；观察组治疗后KPS评分与治疗前相似（>0.05）；观察组治疗后KPS评分高于对照组（<0.05）。观察组治疗后FACT-L总分及各条目评分均高于治疗前（均<0.05）；对照组治疗后FACT-L生理维度评分和情感维度评分均高于治疗前（均<0.05）；观察组治疗后FACT-L总分、生理维度评分、功能维度评分及子量表评分均显著高于对照组（均<0.05），而社会/家庭维度评分和情感维度评分略高于对照组，差异无统计学意义（均>0.05）。两组治疗前后KPS总分差值与FACT-L总分差值呈中度正相关（<0.01）。
火针可提高NSCLC化疗患者的生活质量。
