可持续自由基级联反应合成二氟烷基化吡咯并[1,2-a]吲哚。
Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2-a]indoles.
机构信息
Department of Chemistry and ‡State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University , Fuzhou 350116, China.
出版信息
J Org Chem. 2018 Feb 16;83(4):2425-2437. doi: 10.1021/acs.joc.7b03017. Epub 2018 Feb 6.
PMID:29355010
Abstract
We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo[1,2-a]indoles with a quaternary carbon center under mild conditions.
摘要
我们在此公开了一种 N-(丁烯酰基)吲哚与广泛底物的光催化二氟烷基化和环化级联反应，最高产率可达 90%。该方法在温和条件下提供了可持续且高效的途径，可合成具有季碳原子的二氟烷基化吡咯并[1,2-a]吲哚。
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