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快速生长和慢速生长的商品肉鸡在诱导发生胸肌深部肌病时,其肌肉结构和肌肉中的基因表达情况。

Muscle structure and gene expression in muscle in response to deep pectoral myopathy induction in fast- and slow-growing commercial broilers.

作者信息

Yalcin S, Şahin K, Tuzcu M, Bilgen G, Özkan S, Izzetoğlu G T, Işik R

机构信息

a Faculty of Agriculture, Department of Animal Science , Ege University , İzmir , Turkey.

b Veterinary Faculty, Department of Animal Nutrition , Fırat University , Elazig , Turkey.

出版信息

Br Poult Sci. 2019 Jun;60(3):195-201. doi: 10.1080/00071668.2018.1430351. Epub 2018 Feb 19.

Abstract
  1. The objective of this study was to determine muscle structure and gene expression in muscle of broilers in response to deep pectoral myopathy (DPM) induction. 2. A total of 160 chickens from slow- and fast-growing broilers were raised under same conditions. Half of the broilers from each strain were encouraged to wing flap when they reached 2800 g body weight. muscle of the broilers was inspected for the occurrence of DPM and samples were collected from broilers with or without DPM. The muscle fibre area and number, capillary number and the signalling pathways of vascular development (vascular endothelial growth factor A, ) and muscle contraction regulation () were studied in muscle. 3. DPM induction increased fibre area of muscle with a greater rate in the slow-growing strain compared with fast-growing line. Although the capillary number was higher in slow-growing compared with fast-growing broilers, in the case of DPM induction, the number of capillaries was similar between strains. 4. Expression of and was greater in slow- than in fast-growing broilers. DPM induction increased expression of and in muscle of broilers from both strains; however, expression was downregulated. 5. Changes in capillary density and expression of found in the muscle of broilers with DPM suggest increased blood flow to increase oxygen availability. The upregulation of by DPM induction could be attributable to alterations in calcium ion transportation from the cytoplasm into the sarcoplasmic reticulum. 6. The results are evidence of changes in muscle structure and gene expression pathways in muscle of broilers with DPM.
摘要
  1. 本研究的目的是确定肉仔鸡胸肌在诱发深部胸肌病(DPM)时的肌肉结构和基因表达。2. 从慢速生长和快速生长的肉仔鸡中总共选取160只鸡,在相同条件下饲养。每个品系的一半肉仔鸡在体重达到2800克时被鼓励扑翼。检查肉仔鸡的胸肌是否发生DPM,并从患有或未患DPM的肉仔鸡中采集样本。研究胸肌的肌纤维面积和数量、毛细血管数量以及血管发育(血管内皮生长因子A)和肌肉收缩调节()的信号通路。3. 诱发DPM后,慢速生长品系的胸肌纤维面积增加速率高于快速生长品系。虽然慢速生长的肉仔鸡毛细血管数量高于快速生长的,但在诱发DPM的情况下,各品系之间的毛细血管数量相似。4. 慢速生长的肉仔鸡中 和 的表达高于快速生长的。诱发DPM增加了两个品系肉仔鸡胸肌中 和 的表达;然而, 表达下调。5. DPM肉仔鸡胸肌中毛细血管密度和 表达的变化表明血流量增加以提高氧气供应。DPM诱导导致 上调可能归因于钙离子从细胞质转运到肌浆网的改变。6. 结果证明了患有DPM的肉仔鸡胸肌的肌肉结构和基因表达途径发生了变化。

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