De Keyser J, De Backer J P, Ebinger G, Vauquelin G
J Neurol Sci. 1985 Nov;71(1):119-27. doi: 10.1016/0022-510x(85)90041-3.
Using the [3H]spiroperidol binding technique, we performed a regional distribution of the D2 receptors in the human mesotelencephalic dopamine neuron system. D2 receptors were found in decreasing order of concentration in caudate nucleus greater than putamen greater than nucleus accumbens greater than globus pallidus greater than amygdala greater than substantia nigra. D2 receptors could not be detected in any cortical region. The nigrostriatal and mesolimbic components of the mesotelencephalic dopamine neuron system are easily to reconstitute. If there exists a mesocortical component in man, its actions appear not to be mediated by D2 receptors.
运用[3H]螺哌啶醇结合技术，我们对人类中脑边缘多巴胺神经元系统中的D2受体进行了区域分布研究。发现D2受体浓度从高到低依次为：尾状核大于壳核大于伏隔核大于苍白球大于杏仁核大于黑质。在任何皮质区域均未检测到D2受体。中脑边缘多巴胺神经元系统的黑质纹状体和中脑边缘成分易于重建。如果人类存在中脑皮质成分，其作用似乎并非由D2受体介导。
