Bowersox S S, Kilduff T S, Faull K F, Zeller-DeAmicis L, Dement W C, Ciaranello R D
Brain Res. 1987 Jan 27;402(1):44-8. doi: 10.1016/0006-8993(87)91045-6.
Concentrations of dopamine D2 receptors in discrete brain areas differed significantly between dogs with the genetically transmitted form of narcolepsy, and age- and breed-matched controls. D2 receptors were assayed and quantified with Scatchard analysis using [3H]spiperone. Receptor densities in the nucleus accumbens, rostral caudate, and amygdala were consistently higher in narcoleptic animals. In amygdala, dopamine receptor abnormalities were associated with elevated dopamine and 3,4-dihydroxyphenylacetic acid concentrations, but no change in 3-methoxytyramine or homovanillic acid concentrations. These data indicate mesolimbic system involvement in canine narcolepsy and point to impaired dopamine release as a possible etiologic factor.
遗传性发作性睡病犬与年龄和品种匹配的对照组相比，离散脑区中多巴胺D2受体的浓度存在显著差异。使用[3H]司哌隆通过Scatchard分析对D2受体进行测定和定量。发作性睡病动物伏隔核、尾状核头部和杏仁核中的受体密度始终较高。在杏仁核中，多巴胺受体异常与多巴胺和3,4-二羟基苯乙酸浓度升高有关，但3-甲氧基酪胺或高香草酸浓度没有变化。这些数据表明中脑边缘系统参与犬发作性睡病，并指出多巴胺释放受损可能是一个病因。
