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A tango for two: Dopamine and α-synuclein synergy may explain nigrostriatal degeneration in Parkinson's disease.

作者信息

Chen Vivian, Saez-Atienzar Sara

机构信息

Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.

Transgenics Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, Maryland, USA.

出版信息

Mov Disord. 2018 Feb;33(2):249. doi: 10.1002/mds.27248. Epub 2018 Jan 22.

DOI:10.1002/mds.27248
PMID:29356152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5906791/
Abstract
摘要

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Levodopa Rescues Retinal Function in the Transgenic A53T Alpha-Synuclein Model of Parkinson's Disease.左旋多巴可挽救帕金森病转基因A53Tα-突触核蛋白模型中的视网膜功能。
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Neuronal Vulnerability to Degeneration in Parkinson's Disease and Therapeutic Approaches.帕金森病中神经元易变性与治疗方法。
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The contribution of Parkin, PINK1 and DJ-1 genes to selective neuronal degeneration in Parkinson's disease.Parkin、PINK1 和 DJ-1 基因在帕金森病中对选择性神经元变性的贡献。
Eur J Neurosci. 2020 Aug;52(4):3256-3268. doi: 10.1111/ejn.14689. Epub 2020 Feb 6.

本文引用的文献

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The mutation of two amino acid residues in the N-terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine AtT-20 cells.酪氨酸羟化酶(TH)N端两个氨基酸残基的突变显著增强了神经内分泌AtT-20细胞中的催化活性。
J Neurochem. 2002 Jul;82(1):202-6. doi: 10.1046/j.1471-4159.2002.00921.x.
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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.多巴胺-α-突触核蛋白加合物对α-突触核蛋白原纤维的动力学稳定作用。
Science. 2001 Nov 9;294(5545):1346-9. doi: 10.1126/science.1063522.
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Alpha-synuclein in Lewy bodies.路易小体中的α-突触核蛋白。
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