Department of Pediatrics, University of Alberta, Edmonton, Alberta.
Autism Research Centre, Glenrose Rehabilitation Hospital, Edmonton, Alberta.
Autism Res. 2018 Mar;11(3):539-547. doi: 10.1002/aur.1920. Epub 2018 Jan 22.
Parent and clinician agreement regarding early behavioral signs of Autism Spectrum Disorder (ASD) in children from a high-risk cohort (siblings of children diagnosed with ASD, n = 188) was examined. Infants were assessed prospectively at 12 and 18 months of age using the clinician administered Autism Observational Scale for Infants (AOSI) and the Autism Parent Screen for Infants (APSI) and underwent a blind independent diagnostic assessment for ASD at 36 months of age. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit. The results suggest that parents may detect some clinically informative behaviors based on their day-to-day observations more readily than do clinicians during brief clinical assessments, a result that needs to be replicated in a non-sibling cohort. Autism Res 2018, 11: 539-547. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.
Parents of children at high-risk of autism spectrum disorder (ASD; have an older sibling with ASD) and clinicians were compared on their reporting of 19 early signs of autism. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit. This suggests that parents may have important information regarding early development of their high-risk child.
本研究旨在考察来自高风险队列（自闭症谱系障碍（ASD）患儿的同胞，n=188）的儿童的家长和临床医生对早期行为迹象的一致性。前瞻性地在 12 个月和 18 个月时，使用临床医生实施的婴儿自闭症观察量表（AOSI）和自闭症婴儿父母筛查（APSI）对婴儿进行评估，并在 36 个月时对婴儿进行盲法独立的 ASD 诊断评估。家长和临床医生评分的直接比较显示，在所有早期行为迹象上的一致性都很差，与临床医生在简短的门诊期间的观察相比，在 12 个月和 18 个月时，家长报告的症状更能区分患有和不患有 ASD 的儿童。结果表明，与临床医生在简短的临床评估期间相比，父母可能更易于根据日常观察发现一些具有临床意义的行为，这一结果需要在非同胞队列中得到复制。自闭症研究 2018, 11: 539-547. © 2018 国际自闭症研究协会，威利期刊，公司。
家长和临床医生对 19 项自闭症早期症状的报告进行了比较。家长和临床医生评分的直接比较显示，在所有早期行为迹象上的一致性都很差，与临床医生在简短的门诊期间的观察相比，在 12 个月和 18 个月时，家长报告的症状更能区分患有和不患有 ASD 的儿童。这表明父母可能对其高风险儿童的早期发育有重要的信息。
