1 University of Alberta, Canada.
2 Glenrose Rehabilitation Hospital, Canada.
Autism. 2018 Apr;22(3):322-334. doi: 10.1177/1362361316675120. Epub 2016 Dec 21.
This study examined whether a novel parent-report questionnaire, the Autism Parent Screen for Infants, could differentiate infants subsequently diagnosed with autism spectrum disorder from a high-risk cohort (siblings of children diagnosed with autism spectrum disorder (n = 66)) from high-risk and low-risk comparison infants (no family history of autism spectrum disorder) who did not develop autism spectrum disorder (n = 138 and 79, respectively). Participants were assessed prospectively at 6, 9, 12, 15, 18, and 24 months of age. At 36 months, a blind independent diagnostic assessment for autism spectrum disorder was completed. Parent report on the Autism Parent Screen for Infants was examined in relation to diagnostic outcome and risk status (i.e. high-risk sibling with autism spectrum disorder, high-risk sibling without autism spectrum disorder, and low-risk control). The results indicated that from 6 months of age, total score on the Autism Parent Screen for Infants differentiated between the siblings with autism spectrum disorder and the other two groups. The sensitivity, specificity, and positive and negative predictive validity of the Autism Parent Screen for Infants highlight its potential for the early screening of autism spectrum disorder in high-risk cohorts.
本研究旨在探究一种新型的父母报告问卷——自闭症婴儿家长筛查问卷（Autism Parent Screen for Infants），能否将后续被诊断为自闭症谱系障碍（autism spectrum disorder，ASD）的婴儿与自闭症谱系障碍高风险队列（自闭症谱系障碍患儿的兄弟姐妹，n=66）区分开来，同时还能与自闭症谱系障碍未发病的高风险和低风险对照组婴儿（无自闭症谱系障碍家族史）相区分（分别为 n=138 和 79）。参与者在 6、9、12、15、18 和 24 个月时进行前瞻性评估。在 36 个月时，进行了自闭症谱系障碍的盲法独立诊断评估。通过自闭症婴儿家长筛查问卷的父母报告，来考察其与诊断结果和风险状况（即自闭症谱系障碍患儿的高风险兄弟姐妹、无自闭症谱系障碍的高风险兄弟姐妹和低风险对照组）之间的关系。结果表明，从 6 个月大开始，自闭症婴儿家长筛查问卷的总分就能将自闭症谱系障碍患儿的兄弟姐妹与其他两组区分开来。自闭症婴儿家长筛查问卷的灵敏度、特异性、阳性预测值和阴性预测值均表明，它有可能用于自闭症谱系障碍高风险队列的早期筛查。
