Common duct stricture associated with hepatic artery infusion of FUDR.

A case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct, with the lesion occurring more often than is recognized. A guide is given for the evaluation of the FUDR-infused patient with suspected nonmalignant duct stricture, and for the methods of alleviating extrahepatic blockage in these individuals.