Hephaestus Advanced Laboratory, Eastern Macedonia and Thrace Institute of Technology, Kavala, Greece.
Department of Orthopaedic Surgery, School of Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Ann Biomed Eng. 2018 Apr;46(4):627-639. doi: 10.1007/s10439-018-1983-0. Epub 2018 Jan 22.
An investigation of bone samples taken from the left ulna of New Zealand white rabbits, with and without stresses and hysteresis loop, was undertaken using Small Angle X-ray Scattering technique. The purpose of this study is to investigate the nanostructural changes in the mean size of hydroxyapatite crystals thickness (T) during different mechanical conditions. The experiments were performed using bone samples aged 2 and 4 weeks, with and without strontium ranelate treatment, after compressive load and hysteresis loop. We did not observe any clear effects of strontium ranelate on the bones since the MANOVA test for epiphysis and diaphysis were found. On the other hand, a significant difference appears in epiphysis between 2 and 4 weeks. Furthermore, a reduction in the mean size of hydroxyapatite crystal thickness was observed when the loading pressure force increased, due to the buckling phenomenon. A return of memory points in the elastic region of the bone was observed. The significance of these results lays on the development of nanoproducts, with properties that are closer to the actual bone structure.
采用小角 X 射线散射技术对新西兰白兔左侧桡骨骨样本进行了研究，包括有应力和滞后环的样本和无应力及滞后环的样本。本研究的目的是研究在不同机械条件下，纳米结构中羟磷灰石晶体厚度（T）的平均大小变化。实验使用了经过 2 周和 4 周老化处理的、有或没有雷奈酸锶处理的骨样本，在压缩负载和滞后环后进行实验。由于未发现 MANOVA 检验对骨骺和骨干的明显影响，因此我们没有观察到雷奈酸锶对骨骼的任何明显作用。另一方面，在 2 周和 4 周之间，骨骺处出现了明显的差异。此外，由于屈曲现象，加载压力增加时，羟磷灰石晶体厚度的平均尺寸减小。在骨骼的弹性区域观察到了记忆点的回弹。这些结果的意义在于开发出与实际骨骼结构更接近的纳米产品。
