通过泛素-蛋白酶体系统调节哺乳动物 DNA 复制。
Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
机构信息
Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
出版信息
Adv Exp Med Biol. 2017;1042:421-454. doi: 10.1007/978-981-10-6955-0_19.
Abstract
Proper regulation of DNA replication ensures the faithful transmission of genetic material essential for optimal cellular and organismal physiology. Central to this regulation is the activity of a set of enzymes that induce or reverse posttranslational modifications of various proteins critical for the initiation, progression, and termination of DNA replication. This is particularly important when DNA replication proceeds in cancer cells with elevated rates of genomic instability and increased proliferative capacities. Here, we describe how DNA replication in mammalian cells is regulated via the activity of the ubiquitin-proteasome system as well as the consequence of derailed ubiquitylation signaling involved in this important cellular activity.
摘要
适当的 DNA 复制调控可确保遗传物质的忠实传递，这对于细胞和机体的最佳生理功能至关重要。调控的核心是一组酶的活性，这些酶诱导或逆转各种蛋白质的翻译后修饰，这些蛋白质对 DNA 复制的起始、进行和终止至关重要。当 DNA 复制在具有较高基因组不稳定性和增殖能力的癌细胞中进行时，这一点尤为重要。在这里，我们描述了哺乳动物细胞中的 DNA 复制如何通过泛素-蛋白酶体系统的活性以及与这一重要细胞活动相关的泛素化信号通路紊乱的后果来进行调控。
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