DNA 复制——关乎保真度。
DNA Replication-A Matter of Fidelity.
机构信息
Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden; Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, NY 10016, USA.
Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden.
出版信息
Mol Cell. 2016 Jun 2;62(5):745-55. doi: 10.1016/j.molcel.2016.05.003.
The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.
DNA 复制的保真度由许多因素决定，这里简化为 DNA 聚合酶（核苷酸选择性和校对）、错配修复、核苷酸平衡供应以及 DNA 模板的条件（序列上下文和 DNA 损伤的存在）的贡献。本文讨论了这些因素对 DNA 复制整体保真度的贡献和相互作用。
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