Arimoto Kei-Ichiro, Miyauchi Sayuri, Stoner Samuel A, Fan Jun-Bao, Zhang Dong-Er
Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.
J Leukoc Biol. 2018 Jan 22. doi: 10.1002/JLB.2MIR0817-342R.
Type I IFNs (α, β, and others) are a family of cytokines that are produced in physiological conditions as well as in response to the activation of pattern recognition receptors. They are critically important in controlling the host innate and adaptive immune response to viral and some bacterial infections, cancer, and other inflammatory stimuli. However, dysregulation of type I IFN production or response can contribute to immune pathologies termed "interferonopathies", pointing to the importance of balanced activating signals with tightly regulated mechanisms of tuning this signaling. Here, we summarize the recent advances of how type I IFN production and response are controlled at multiple levels of the type I IFN signaling cascade.
I型干扰素（α、β及其他类型）是一类细胞因子，在生理条件下以及模式识别受体激活后均会产生。它们在控制宿主对病毒和某些细菌感染、癌症及其他炎症刺激的先天性和适应性免疫反应中至关重要。然而，I型干扰素产生或反应的失调会导致被称为“干扰素病”的免疫病理状况，这表明具有严格调控机制来调节该信号传导的平衡激活信号的重要性。在此，我们总结了I型干扰素信号级联反应多个层面上I型干扰素产生和反应如何受到控制的最新进展。
